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TIRAP

GENERAL INFORMATION

Gene name

 TIRAP

Gene description

 Toll-interleukin 1 receptor (TIR) domain containing adaptor protein

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA054431
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA054431

GENE INFORMATION

Gene name

 TIRAP (HGNC Symbol)

Synonyms

 Mal, wyatt

Description

 Toll-interleukin 1 receptor (TIR) domain containing adaptor protein (HGNC Symbol)

Entrez gene summary

 The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q24.2

Chromosome location (bp)

 126283065 - 126298845

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000150455 (version 83.38)

Entrez gene

 114609

UniProt

 P58753 (UniProt - Evidence at protein level)

neXtProt

 NX_P58753

Antibodypedia

 TIRAP antibodies

PROTEIN BROWSER
TIRAP-001
TIRAP-002
TIRAP-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TIRAP-001
ENSP00000376446
ENST00000392679
P58753 [Direct mapping]
Toll/interleukin-1 receptor domain-containing adapter protein
A0A024R3M4 [Target identity:100%; Query identity:100%]
Toll-interleukin 1 receptor (TIR) domain containing adaptor protein, isoform CRA_a
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Predicted intracellular proteins
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GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0030099 [myeloid cell differentiation]
GO:0030139 [endocytic vesicle]
GO:0030674 [protein binding, bridging]
GO:0030890 [positive regulation of B cell proliferation]
GO:0032496 [response to lipopolysaccharide]
GO:0032587 [ruffle membrane]
GO:0032648 [regulation of interferon-beta production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032738 [positive regulation of interleukin-15 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034137 [positive regulation of toll-like receptor 2 signaling pathway]
GO:0034141 [positive regulation of toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway]
GO:0035662 [Toll-like receptor 4 binding]
GO:0035663 [Toll-like receptor 2 binding]
GO:0035665 [TIRAP-dependent toll-like receptor 4 signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0044130 [negative regulation of growth of symbiont in host]
GO:0045087 [innate immune response]
GO:0045088 [regulation of innate immune response]
GO:0045171 [intercellular bridge]
GO:0045410 [positive regulation of interleukin-6 biosynthetic process]
GO:0046330 [positive regulation of JNK cascade]
GO:0046982 [protein heterodimerization activity]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070935 [3'-UTR-mediated mRNA stabilization]
GO:0071221 [cellular response to bacterial lipopeptide]
GO:0071223 [cellular response to lipoteichoic acid]
GO:0090023 [positive regulation of neutrophil chemotaxis]
GO:0090073 [positive regulation of protein homodimerization activity]
GO:2000340 [positive regulation of chemokine (C-X-C motif) ligand 1 production]
GO:2000343 [positive regulation of chemokine (C-X-C motif) ligand 2 production]
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 221 aa
23.9 kDa 		No 0
TIRAP-002
ENSP00000376447
ENST00000392680
P58753 [Direct mapping]
Toll/interleukin-1 receptor domain-containing adapter protein
A0A024R3M4 [Target identity:100%; Query identity:100%]
Toll-interleukin 1 receptor (TIR) domain containing adaptor protein, isoform CRA_a
Show all
Predicted intracellular proteins
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0030099 [myeloid cell differentiation]
GO:0030139 [endocytic vesicle]
GO:0030674 [protein binding, bridging]
GO:0030890 [positive regulation of B cell proliferation]
GO:0032496 [response to lipopolysaccharide]
GO:0032587 [ruffle membrane]
GO:0032648 [regulation of interferon-beta production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032738 [positive regulation of interleukin-15 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034137 [positive regulation of toll-like receptor 2 signaling pathway]
GO:0034141 [positive regulation of toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway]
GO:0035662 [Toll-like receptor 4 binding]
GO:0035663 [Toll-like receptor 2 binding]
GO:0035665 [TIRAP-dependent toll-like receptor 4 signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0044130 [negative regulation of growth of symbiont in host]
GO:0045087 [innate immune response]
GO:0045088 [regulation of innate immune response]
GO:0045171 [intercellular bridge]
GO:0045410 [positive regulation of interleukin-6 biosynthetic process]
GO:0046330 [positive regulation of JNK cascade]
GO:0046982 [protein heterodimerization activity]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070935 [3'-UTR-mediated mRNA stabilization]
GO:0071221 [cellular response to bacterial lipopeptide]
GO:0071223 [cellular response to lipoteichoic acid]
GO:0090023 [positive regulation of neutrophil chemotaxis]
GO:0090073 [positive regulation of protein homodimerization activity]
GO:2000340 [positive regulation of chemokine (C-X-C motif) ligand 1 production]
GO:2000343 [positive regulation of chemokine (C-X-C motif) ligand 2 production]
Show all
 221 aa
23.9 kDa 		No 0
TIRAP-003
ENSP00000376445
ENST00000392678
P58753 [Direct mapping]
Toll/interleukin-1 receptor domain-containing adapter protein
Show all
Predicted intracellular proteins
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0030099 [myeloid cell differentiation]
GO:0030139 [endocytic vesicle]
GO:0030674 [protein binding, bridging]
GO:0030890 [positive regulation of B cell proliferation]
GO:0032496 [response to lipopolysaccharide]
GO:0032587 [ruffle membrane]
GO:0032648 [regulation of interferon-beta production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032738 [positive regulation of interleukin-15 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034137 [positive regulation of toll-like receptor 2 signaling pathway]
GO:0034141 [positive regulation of toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway]
GO:0035662 [Toll-like receptor 4 binding]
GO:0035663 [Toll-like receptor 2 binding]
GO:0035665 [TIRAP-dependent toll-like receptor 4 signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0044130 [negative regulation of growth of symbiont in host]
GO:0045087 [innate immune response]
GO:0045088 [regulation of innate immune response]
GO:0045171 [intercellular bridge]
GO:0045410 [positive regulation of interleukin-6 biosynthetic process]
GO:0046330 [positive regulation of JNK cascade]
GO:0046982 [protein heterodimerization activity]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070935 [3'-UTR-mediated mRNA stabilization]
GO:0071221 [cellular response to bacterial lipopeptide]
GO:0071223 [cellular response to lipoteichoic acid]
GO:0090023 [positive regulation of neutrophil chemotaxis]
GO:0090073 [positive regulation of protein homodimerization activity]
GO:2000340 [positive regulation of chemokine (C-X-C motif) ligand 1 production]
GO:2000343 [positive regulation of chemokine (C-X-C motif) ligand 2 production]
Show all
 235 aa
25.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.