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LATS2

GENERAL INFORMATION

Gene name

 LATS2

Gene description

 Large tumor suppressor kinase 2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA039191
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (unfavourable).
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039191

GENE INFORMATION

Gene name

 LATS2

Synonyms

Description

 Large tumor suppressor kinase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]

Chromosome

 13

Cytoband

 q12.11

Chromosome location (bp)

 20973032 - 21061547

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000150457 (version 83.38)

Entrez gene

 26524

UniProt

 Q9NRM7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NRM7

Antibodypedia

 LATS2 antibodies

PROTEIN BROWSER
LATS2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LATS2-001
ENSP00000372035
ENST00000382592
Q9NRM7 [Direct mapping]
Serine/threonine-protein kinase LATS2
A0A024RDM3 [Target identity:100%; Query identity:100%]
LATS, large tumor suppressor, homolog 2 (Drosophila), isoform CRA_a
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0001827 [inner cell mass cell fate commitment]
GO:0001828 [inner cell mass cellular morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0009755 [hormone-mediated signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030216 [keratinocyte differentiation]
GO:0034613 [cellular protein localization]
GO:0035329 [hippo signaling]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0046620 [regulation of organ growth]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
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 1088 aa
120.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.