Cell atlas - SAP18 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

SAP18

premium

TISSUE

premium

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear bodies
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	SAP18
Gene description	Sin3A-associated protein, 18kDa
Protein class	Predicted intracellular proteins Transporters
Predicted localization	Intracellular
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear bodies & nucleoplasm. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported), Nuclear bodies (supported)
Additional location	In addition localized to the Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA011352
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear bodies & nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (supported), Nuclear bodies (supported)

Additional location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA011352	A-431	Nucleoplasm
	HPA011352	A-431	Nuclear bodies
	HPA011352	U-2 OS	Nucleoplasm
	HPA011352	U-2 OS	Nuclear bodies
	HPA011352	U-251 MG	Nucleoplasm
	HPA011352	U-251 MG	Cytosol

GENE INFORMATION
Gene name	SAP18 (HGNC Symbol)
Synonyms	2HOR0202, MGC27131, SAP18p
Description	Sin3A-associated protein, 18kDa (HGNC Symbol)
Entrez gene summary	Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008]
Chromosome	13
Cytoband	q12.11
Chromosome location (bp)	21140514 - 21149084
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000150459 (version 83.38)
Entrez gene	10284
UniProt	O00422 (UniProt - Evidence at protein level)
neXtProt	NX_O00422
Antibodypedia	SAP18 antibodies

PROTEIN BROWSER

SAP18-001	SAP18-005	SAP18-006	SAP18-008	SAP18-009	SAP18-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SAP18-001 ENSP00000371973 ENST00000382533	X6RAL5 [Direct mapping] Histone deacetylase complex subunit SAP18 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		172 aa 19.5 kDa	No	0
SAP18-005 ENSP00000475358 ENST00000467636	U3KPY7 [Direct mapping] Histone deacetylase complex subunit SAP18 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		78 aa 9.1 kDa	No	0
SAP18-006 ENSP00000475435 ENST00000492245	U3KQ12 [Direct mapping] Histone deacetylase complex subunit SAP18 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		59 aa 6.8 kDa	No	0
SAP18-008 ENSP00000391846 ENST00000450573	H7BZW6 [Direct mapping] Histone deacetylase complex subunit SAP18 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	143 aa 16 kDa	No	0
SAP18-009 ENSP00000475925 ENST00000607003	O00422 [Direct mapping] Histone deacetylase complex subunit SAP18 Show all	Transporters Primary Active Transporters Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000118 [histone deacetylase complex] GO:0000381 [regulation of alternative mRNA splicing, via spliceosome] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006397 [mRNA processing] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0016607 [nuclear speck] GO:0035145 [exon-exon junction complex] GO:0040029 [regulation of gene expression, epigenetic] GO:0043065 [positive regulation of apoptotic process] GO:0044822 [poly(A) RNA binding] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0048025 [negative regulation of mRNA splicing, via spliceosome] GO:0061574 [ASAP complex] GO:1903507 [negative regulation of nucleic acid-templated transcription] Show all	153 aa 17.6 kDa	No	0
SAP18-201 ENSP00000481842 ENST00000621421	X6RAL5 [Direct mapping] Histone deacetylase complex subunit SAP18 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		172 aa 19.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.