Expression of CTAGE5 in cancer - Summary

GENERAL INFORMATION
Gene name	CTAGE5
Gene description	CTAGE family, member 5
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	11
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues, most abundant in glandular and neuronal cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA000387 , HPA000922
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA000387	HPA000922

GENE INFORMATION
Gene name	CTAGE5 (HGNC Symbol)
Synonyms	cTAGE-5A, cTAGE-5B, cTAGE-5C, cTAGE-5D, MEA6, MGEA, MGEA11, MGEA6
Description	CTAGE family, member 5 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a tumor-associated antigen found in cutaneous T-cell lymphoma and several other cancers. Autoantibodies against the encoded protein have been found in some cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Chromosome	14
Cytoband	q21.1
Chromosome location (bp)	39265284 - 39388513
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000150527 (version 83.38)
Entrez gene	4253
UniProt	O15320 (UniProt - Evidence at protein level)
neXtProt	NX_O15320
Antibodypedia	CTAGE5 antibodies

PROTEIN BROWSER

CTAGE5-001	CTAGE5-002	CTAGE5-003	CTAGE5-004	CTAGE5-005	CTAGE5-006	CTAGE5-007	CTAGE5-010	CTAGE5-014	CTAGE5-015	CTAGE5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CTAGE5-001 ENSP00000343897 ENST00000341749	O15320 [Direct mapping] cTAGE family member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0008047 [enzyme activator activity] GO:0016020 [membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043085 [positive regulation of catalytic activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0061024 [membrane organization] Show all	792 aa 89.6 kDa	No	1
CTAGE5-002 ENSP00000280083 ENST00000280083	O15320 [Direct mapping] cTAGE family member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0008047 [enzyme activator activity] GO:0016020 [membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043085 [positive regulation of catalytic activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0061024 [membrane organization] Show all	804 aa 91 kDa	No	1
CTAGE5-003 ENSP00000343912 ENST00000348007	O15320 [Direct mapping] cTAGE family member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0008047 [enzyme activator activity] GO:0016020 [membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043085 [positive regulation of catalytic activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0061024 [membrane organization] Show all	761 aa 86.5 kDa	No	1
CTAGE5-004 ENSP00000379468 ENST00000396165	O15320 [Direct mapping] cTAGE family member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0008047 [enzyme activator activity] GO:0016020 [membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043085 [positive regulation of catalytic activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0061024 [membrane organization] Show all	775 aa 87.8 kDa	No	1
CTAGE5-005 ENSP00000450449 ENST00000553352	O15320 [Direct mapping] cTAGE family member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0008047 [enzyme activator activity] GO:0016020 [membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043085 [positive regulation of catalytic activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0061024 [membrane organization] Show all	775 aa 87.8 kDa	No	1
CTAGE5-006 ENSP00000452562 ENST00000556148	O15320 [Direct mapping] cTAGE family member 5 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0008047 [enzyme activator activity] GO:0016020 [membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043085 [positive regulation of catalytic activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0061024 [membrane organization] Show all	729 aa 82.4 kDa	No	0
CTAGE5-007 ENSP00000450869 ENST00000557038	O15320 [Direct mapping] cTAGE family member 5 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0008047 [enzyme activator activity] GO:0016020 [membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043085 [positive regulation of catalytic activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0061024 [membrane organization] Show all	724 aa 81.8 kDa	No	0
CTAGE5-010 ENSP00000451164 ENST00000554392	G3V3C4 [Direct mapping] cTAGE family member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	138 aa 15.7 kDa	No	1
CTAGE5-014 ENSP00000452395 ENST00000555716	G3V5K6 [Direct mapping] cTAGE family member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	151 aa 17.4 kDa	No	1
CTAGE5-015 ENSP00000339286 ENST00000341502	O15320 [Direct mapping] cTAGE family member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0008047 [enzyme activator activity] GO:0016020 [membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043085 [positive regulation of catalytic activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0061024 [membrane organization] Show all	771 aa 86.8 kDa	No	1
CTAGE5-201 ENSP00000379462 ENST00000396158	O15320 [Direct mapping] cTAGE family member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0008047 [enzyme activator activity] GO:0016020 [membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043085 [positive regulation of catalytic activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0061024 [membrane organization] Show all	809 aa 91.6 kDa	No	1