Expression of GPM6A in cancer - Summary

GENERAL INFORMATION
Gene name	GPM6A
Gene description	Glycoprotein M6A
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	18
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (glioma)
HPA (cell line):	Group enriched (AF22, Daudi, U-251 MG)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.
Reliability score	Supported based on 1 antibody. HPA017338
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA017338

GENE INFORMATION
Gene name	GPM6A (HGNC Symbol)
Synonyms	GPM6
Description	Glycoprotein M6A (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	q34.2
Chromosome location (bp)	175632934 - 176002664
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000150625 (version 83.38)
Entrez gene	2823
UniProt	P51674 (UniProt - Evidence at protein level)
neXtProt	NX_P51674
Antibodypedia	GPM6A antibodies

PROTEIN BROWSER

GPM6A-001	GPM6A-002	GPM6A-003	GPM6A-004	GPM6A-006	GPM6A-007	GPM6A-008	GPM6A-009	GPM6A-010	GPM6A-011	GPM6A-012	GPM6A-013	GPM6A-014	GPM6A-015	GPM6A-016	GPM6A-017	GPM6A-018	GPM6A-020

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPM6A-001 ENSP00000421578 ENST00000506894	P51674 [Direct mapping] Neuronal membrane glycoprotein M6-a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001764 [neuron migration] GO:0003407 [neural retina development] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007416 [synapse assembly] GO:0016021 [integral component of membrane] GO:0030175 [filopodium] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0043197 [dendritic spine] GO:0044295 [axonal growth cone] GO:0048812 [neuron projection morphogenesis] GO:0048863 [stem cell differentiation] GO:0051491 [positive regulation of filopodium assembly] GO:0070062 [extracellular exosome] GO:1903561 [extracellular vesicle] Show all	267 aa 29.9 kDa	No	4
GPM6A-002 ENSP00000377268 ENST00000393658	P51674 [Direct mapping] Neuronal membrane glycoprotein M6-a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001764 [neuron migration] GO:0003407 [neural retina development] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007416 [synapse assembly] GO:0016021 [integral component of membrane] GO:0030175 [filopodium] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0043197 [dendritic spine] GO:0044295 [axonal growth cone] GO:0048812 [neuron projection morphogenesis] GO:0048863 [stem cell differentiation] GO:0051491 [positive regulation of filopodium assembly] GO:0070062 [extracellular exosome] GO:1903561 [extracellular vesicle] Show all	278 aa 31.2 kDa	No	4
GPM6A-003 ENSP00000280187 ENST00000280187	P51674 [Direct mapping] Neuronal membrane glycoprotein M6-a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001764 [neuron migration] GO:0003407 [neural retina development] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007416 [synapse assembly] GO:0016021 [integral component of membrane] GO:0030175 [filopodium] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0043197 [dendritic spine] GO:0044295 [axonal growth cone] GO:0048812 [neuron projection morphogenesis] GO:0048863 [stem cell differentiation] GO:0051491 [positive regulation of filopodium assembly] GO:0070062 [extracellular exosome] GO:0070588 [calcium ion transmembrane transport] GO:1903561 [extracellular vesicle] Show all	278 aa 31.2 kDa	No	4
GPM6A-004 ENSP00000423984 ENST00000515090	P51674 [Direct mapping] Neuronal membrane glycoprotein M6-a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001764 [neuron migration] GO:0003407 [neural retina development] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007416 [synapse assembly] GO:0016021 [integral component of membrane] GO:0030175 [filopodium] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0043197 [dendritic spine] GO:0044295 [axonal growth cone] GO:0048812 [neuron projection morphogenesis] GO:0048863 [stem cell differentiation] GO:0051491 [positive regulation of filopodium assembly] GO:0070062 [extracellular exosome] GO:1903561 [extracellular vesicle] Show all	271 aa 30.4 kDa	No	4
GPM6A-006 ENSP00000424443 ENST00000512509	D6RB41 [Direct mapping] Neuronal membrane glycoprotein M6-a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	87 aa 9.8 kDa	No	2
GPM6A-007 ENSP00000426821 ENST00000502754	D6REJ8 [Direct mapping] Neuronal membrane glycoprotein M6-a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	117 aa 13.3 kDa	No	2
GPM6A-008 ENSP00000422959 ENST00000503397	D6R9D2 [Direct mapping] Neuronal membrane glycoprotein M6-a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	218 aa 24 kDa	No	4
GPM6A-009 ENSP00000422712 ENST00000509865	D6RAE4 [Direct mapping] Neuronal membrane glycoprotein M6-a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	50 aa 5.5 kDa	No	1
GPM6A-010 ENSP00000426352 ENST00000503563		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		10 aa 1.2 kDa	No	0
GPM6A-011 ENSP00000421373 ENST00000513667	D6RFZ3 [Direct mapping] Neuronal membrane glycoprotein M6-a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	98 aa 11.2 kDa	No	2
GPM6A-012 ENSP00000423122 ENST00000513365	D6R9T7 [Direct mapping] Neuronal membrane glycoprotein M6-a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	129 aa 14.1 kDa	No	2
GPM6A-013 ENSP00000421407 ENST00000507540	D6RFY0 [Direct mapping] Neuronal membrane glycoprotein M6-a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	41 aa 4.6 kDa	No	1
GPM6A-014 ENSP00000426984 ENST00000512610	D6RDV7 [Direct mapping] Neuronal membrane glycoprotein M6-a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	119 aa 13.5 kDa	No	2
GPM6A-015 ENSP00000424125 ENST00000505375	D6RBH3 [Direct mapping] Neuronal membrane glycoprotein M6-a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	82 aa 9.2 kDa	No	2
GPM6A-016 ENSP00000425409 ENST00000505561	D6RD95 [Direct mapping] Neuronal membrane glycoprotein M6-a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	89 aa 9.9 kDa	No	2
GPM6A-017 ENSP00000425925 ENST00000512897	D6RIF4 [Direct mapping] Neuronal membrane glycoprotein M6-a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	44 aa 4.9 kDa	No	1
GPM6A-018 ENSP00000425463 ENST00000505304	D6RD71 [Direct mapping] Neuronal membrane glycoprotein M6-a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	66 aa 7 kDa	No	1
GPM6A-020 ENSP00000424075 ENST00000507520	D6RBM6 [Direct mapping] Neuronal membrane glycoprotein M6-a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	105 aa 12 kDa	No	2