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Vascular endothelial growth factor C (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014]
P49767 [Direct mapping] Vascular endothelial growth factor C
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Transporters Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001525 [angiogenesis] GO:0001954 [positive regulation of cell-matrix adhesion] GO:0002052 [positive regulation of neuroblast proliferation] GO:0002576 [platelet degranulation] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006929 [substrate-dependent cell migration] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] GO:0008083 [growth factor activity] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0009887 [organ morphogenesis] GO:0016020 [membrane] GO:0016331 [morphogenesis of embryonic epithelium] GO:0030168 [platelet activation] GO:0030947 [regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031093 [platelet alpha granule lumen] GO:0031954 [positive regulation of protein autophosphorylation] GO:0042056 [chemoattractant activity] GO:0042493 [response to drug] GO:0043185 [vascular endothelial growth factor receptor 3 binding] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0045766 [positive regulation of angiogenesis] GO:0045776 [negative regulation of blood pressure] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050714 [positive regulation of protein secretion] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050918 [positive chemotaxis] GO:0050930 [induction of positive chemotaxis] GO:0051781 [positive regulation of cell division] GO:0060754 [positive regulation of mast cell chemotaxis] GO:1901492 [positive regulation of lymphangiogenesis]