Expression of CD226 in cancer - Summary - The Human Protein Atlas

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CD226

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CD226
Gene description	CD226 molecule
Protein class	CD markers Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Group enriched (HEL, HMC-1)
HPA (normal tissue):	Tissue enriched (parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in subsets of immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	External characterization data supports antibody staining. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 1 antibody. HPA015715
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA015715

GENE INFORMATION
Gene name	CD226 (HGNC Symbol)
Synonyms	DNAM-1, DNAM1, PTA1, TLiSA1
Description	CD226 molecule (HGNC Symbol)
Entrez gene summary	This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Chromosome	18
Cytoband	q22.2
Chromosome location (bp)	69831158 - 69961803
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000150637 (version 83.38)
Entrez gene	10666
UniProt	Q15762 (UniProt - Evidence at protein level)
neXtProt	NX_Q15762
Antibodypedia	CD226 antibodies

PROTEIN BROWSER

CD226-001	CD226-003	CD226-004	CD226-005	CD226-006	CD226-007	CD226-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD226-001 ENSP00000280200 ENST00000280200	Q15762 [Direct mapping] CD226 antigen Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001816 [cytokine production] GO:0002860 [positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target] GO:0002891 [positive regulation of immunoglobulin mediated immune response] GO:0004872 [receptor activity] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005913 [cell-cell adherens junction] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007165 [signal transduction] GO:0008037 [cell recognition] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0019901 [protein kinase binding] GO:0033005 [positive regulation of mast cell activation] GO:0042803 [protein homodimerization activity] GO:0045121 [membrane raft] GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity] GO:0050776 [regulation of immune response] GO:0050839 [cell adhesion molecule binding] GO:0060369 [positive regulation of Fc receptor mediated stimulatory signaling pathway] Show all	336 aa 38.6 kDa	Yes	1
CD226-003 ENSP00000464084 ENST00000581982	J3QR77 [Direct mapping] CD226 antigen Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	181 aa 21.1 kDa	No	1
CD226-004 ENSP00000461947 ENST00000582621	Q15762 [Direct mapping] CD226 antigen Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0002860 [positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target] GO:0002891 [positive regulation of immunoglobulin mediated immune response] GO:0004872 [receptor activity] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005913 [cell-cell adherens junction] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007165 [signal transduction] GO:0008037 [cell recognition] GO:0009986 [cell surface] GO:0019901 [protein kinase binding] GO:0033005 [positive regulation of mast cell activation] GO:0042803 [protein homodimerization activity] GO:0045121 [membrane raft] GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity] GO:0050776 [regulation of immune response] GO:0050839 [cell adhesion molecule binding] GO:0060369 [positive regulation of Fc receptor mediated stimulatory signaling pathway] Show all	336 aa 38.6 kDa	Yes	1
CD226-005 ENSP00000463335 ENST00000580335	J3QL19 [Direct mapping] CD226 antigen Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	127 aa 14.6 kDa	Yes	0
CD226-006 ENSP00000464334 ENST00000583955	J3QRQ4 [Direct mapping] CD226 antigen Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	132 aa 15.2 kDa	Yes	0
CD226-007 ENSP00000462453 ENST00000577287	J3QR77 [Direct mapping] CD226 antigen Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	181 aa 21.1 kDa	No	1
CD226-009 ENSP00000463927 ENST00000579496	J3QQW1 [Direct mapping] CD226 antigen Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	276 aa 31.3 kDa	Yes	1

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