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PRSS23

GENERAL INFORMATION

Gene name

 PRSS23

Gene description

 Protease, serine, 23

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Extracellular positivity and cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA030591
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PRSS23 (HGNC Symbol)

Synonyms

 SIG13, SPUVE

Description

 Protease, serine, 23 (HGNC Symbol)

Entrez gene summary

 This gene encodes a conserved member of the trypsin family of serine proteases. Mouse studies found a decrease of mRNA levels of this gene after ovulation was induced. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Chromosome

 11

Cytoband

 q14.2

Chromosome location (bp)

 86791059 - 86952910

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000150687 (version 83.38)

Entrez gene

 11098

UniProt

 O95084 (UniProt - Evidence at protein level)

neXtProt

 NX_O95084

Antibodypedia

 PRSS23 antibodies

PROTEIN BROWSER
PRSS23-001
PRSS23-004
PRSS23-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRSS23-001
ENSP00000280258
ENST00000280258
O95084 [Direct mapping]
Serine protease 23
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Enzymes
   Peptidases
   Serine-type peptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005634 [nucleus]
GO:0006508 [proteolysis]
GO:0070062 [extracellular exosome]
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 383 aa
43 kDa 		Yes 0
PRSS23-004
ENSP00000437268
ENST00000533902
E9PMX2 [Direct mapping]
Serine protease 23
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 91 aa
10.3 kDa 		No 0
PRSS23-005
ENSP00000435951
ENST00000527521
E9PRR2 [Direct mapping]
Serine protease 23
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 154 aa
16.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.