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CCT5

GENERAL INFORMATION

Gene name

 CCT5

Gene description

 Chaperonin containing TCP1, subunit 5 (epsilon)

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression, most abundant in seminiferous duct cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Nuclear positivity in CNS viewed as off target and disregarded.

Reliability score

 Supported based on 3 antibodies.
HPA002238 , HPA005958 , CAB006271
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA002238
HPA005958
CAB006271

GENE INFORMATION

Gene name

 CCT5 (HGNC Symbol)

Synonyms

 KIAA0098

Description

 Chaperonin containing TCP1, subunit 5 (epsilon) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]

Chromosome

 5

Cytoband

 p15.2

Chromosome location (bp)

 10249921 - 10266412

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000150753 (version 83.38)

Entrez gene

 22948

UniProt

 P48643 (UniProt - Evidence at protein level)

neXtProt

 NX_P48643

Antibodypedia

 CCT5 antibodies

PROTEIN BROWSER
CCT5-001
CCT5-002
CCT5-003
CCT5-013
CCT5-014
CCT5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCT5-001
ENSP00000280326
ENST00000280326
P48643 [Direct mapping]
T-complex protein 1 subunit epsilon
V9HW37 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 69
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002199 [zona pellucida receptor complex]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005832 [chaperonin-containing T-complex]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0007339 [binding of sperm to zona pellucida]
GO:0009615 [response to virus]
GO:0031681 [G-protein beta-subunit binding]
GO:0043209 [myelin sheath]
GO:0044267 [cellular protein metabolic process]
GO:0044297 [cell body]
GO:0048487 [beta-tubulin binding]
GO:0051082 [unfolded protein binding]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0070062 [extracellular exosome]
GO:1901998 [toxin transport]
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 541 aa
59.7 kDa 		No 0
CCT5-002
ENSP00000423318
ENST00000503026
E9PCA1 [Direct mapping]
T-complex protein 1 subunit epsilon
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005524 [ATP binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
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 520 aa
57.1 kDa 		No 0
CCT5-003
ENSP00000426923
ENST00000515390
E7ENZ3 [Direct mapping]
T-complex protein 1 subunit epsilon
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
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 486 aa
53.8 kDa 		No 0
CCT5-013
ENSP00000427297
ENST00000515676
B7ZAR1 [Direct mapping]
T-complex protein 1 subunit epsilon; cDNA, FLJ79275, highly similar to T-complex protein 1 subunit epsilon
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
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 503 aa
55.3 kDa 		No 0
CCT5-014
ENSP00000423052
ENST00000506600
P48643 [Direct mapping]
T-complex protein 1 subunit epsilon
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005832 [chaperonin-containing T-complex]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0009615 [response to virus]
GO:0031681 [G-protein beta-subunit binding]
GO:0044267 [cellular protein metabolic process]
GO:0048487 [beta-tubulin binding]
GO:0051082 [unfolded protein binding]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0070062 [extracellular exosome]
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 448 aa
49.5 kDa 		No 0
CCT5-201
ENSP00000487128
ENST00000625723
D6RIZ7 [Direct mapping]
T-complex protein 1 subunit epsilon
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 44 aa
4.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.