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IL18

GENERAL INFORMATION

Gene name

 IL18

Gene description

 Interleukin 18

Protein class

 Cancer-related genes
Candidate cardiovascular disease genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (CAPAN-2, HaCaT, hTCEpi, U-2 OS)
HPA (normal tissue):Tissue enhanced (esophagus, skin)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in squamous epithelium while subsets of lymphoid cells showed cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA003980 , CAB007772
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable).
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA003980
CAB007772

GENE INFORMATION

Gene name

 IL18 (HGNC Symbol)

Synonyms

 IGIF, IL-18, IL-1g, IL1F4

Description

 Interleukin 18 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

Chromosome

 11

Cytoband

 q23.1

Chromosome location (bp)

 112143251 - 112164117

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000150782 (version 83.38)

Entrez gene

 3606

UniProt

 Q14116 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14116

Antibodypedia

 IL18 antibodies

PROTEIN BROWSER
IL18-001
IL18-003
IL18-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IL18-001
ENSP00000280357
ENST00000280357
Q14116 [Direct mapping]
Interleukin-18
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0001525 [angiogenesis]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007267 [cell-cell signaling]
GO:0010628 [positive regulation of gene expression]
GO:0030101 [natural killer cell activation]
GO:0030155 [regulation of cell adhesion]
GO:0030431 [sleep]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032725 [positive regulation of granulocyte macrophage colony-stimulating factor production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0032819 [positive regulation of natural killer cell proliferation]
GO:0034105 [positive regulation of tissue remodeling]
GO:0042033 [chemokine biosynthetic process]
GO:0042088 [T-helper 1 type immune response]
GO:0042092 [type 2 immune response]
GO:0042094 [interleukin-2 biosynthetic process]
GO:0042095 [interferon-gamma biosynthetic process]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0042231 [interleukin-13 biosynthetic process]
GO:0042253 [granulocyte macrophage colony-stimulating factor biosynthetic process]
GO:0042346 [positive regulation of NF-kappaB import into nucleus]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0045662 [negative regulation of myoblast differentiation]
GO:0050729 [positive regulation of inflammatory response]
GO:0051142 [positive regulation of NK T cell proliferation]
GO:0070062 [extracellular exosome]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071407 [cellular response to organic cyclic compound]
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 193 aa
22.3 kDa 		No 0
IL18-003
ENSP00000434561
ENST00000524595
Q14116 [Direct mapping]
Interleukin-18
A0A024R3E0 [Target identity:100%; Query identity:100%]
Interleukin 18 (Interferon-gamma-inducing factor), isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0001525 [angiogenesis]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007267 [cell-cell signaling]
GO:0030155 [regulation of cell adhesion]
GO:0030431 [sleep]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032725 [positive regulation of granulocyte macrophage colony-stimulating factor production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0032819 [positive regulation of natural killer cell proliferation]
GO:0034105 [positive regulation of tissue remodeling]
GO:0042033 [chemokine biosynthetic process]
GO:0042088 [T-helper 1 type immune response]
GO:0042092 [type 2 immune response]
GO:0042094 [interleukin-2 biosynthetic process]
GO:0042095 [interferon-gamma biosynthetic process]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0042231 [interleukin-13 biosynthetic process]
GO:0042253 [granulocyte macrophage colony-stimulating factor biosynthetic process]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0050729 [positive regulation of inflammatory response]
GO:0051142 [positive regulation of NK T cell proliferation]
GO:0070062 [extracellular exosome]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071407 [cellular response to organic cyclic compound]
Show all
 189 aa
21.9 kDa 		No 0
IL18-006
ENSP00000434161
ENST00000528832
Q14116 [Direct mapping]
Interleukin-18
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0001525 [angiogenesis]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007267 [cell-cell signaling]
GO:0030155 [regulation of cell adhesion]
GO:0030431 [sleep]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032725 [positive regulation of granulocyte macrophage colony-stimulating factor production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0032819 [positive regulation of natural killer cell proliferation]
GO:0034105 [positive regulation of tissue remodeling]
GO:0042033 [chemokine biosynthetic process]
GO:0042088 [T-helper 1 type immune response]
GO:0042092 [type 2 immune response]
GO:0042094 [interleukin-2 biosynthetic process]
GO:0042095 [interferon-gamma biosynthetic process]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0042231 [interleukin-13 biosynthetic process]
GO:0042253 [granulocyte macrophage colony-stimulating factor biosynthetic process]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0050729 [positive regulation of inflammatory response]
GO:0051142 [positive regulation of NK T cell proliferation]
GO:0070062 [extracellular exosome]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071407 [cellular response to organic cyclic compound]
Show all
 193 aa
22.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.