Cell atlas - FREM2 - The Human Protein Atlas

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FREM2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	FREM2
Gene description	FRAS1 related extracellular matrix protein 2
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (AF22, MCF7, WM-115, RT4)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA028831
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AF22, MCF7, WM-115, RT4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA028831	U-2 OS	Cytosol
	HPA028831	U-251 MG	Cytosol

GENE INFORMATION
Gene name	FREM2 (HGNC Symbol)
Synonyms	DKFZp686J0811
Description	FRAS1 related extracellular matrix protein 2 (HGNC Symbol)
Entrez gene summary	This gene encodes an integral membrane protein containing numerous CSPG (chondroitin sulfate proteoglycan element) repeats and Calx-beta domains. The encoded protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions. This protein is important for the integrity of skin and renal epithelia. Mutations in this gene are associated with Fraser syndrome. [provided by RefSeq, Apr 2014]
Chromosome	13
Cytoband	q13.3
Chromosome location (bp)	38687129 - 38887131
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000150893 (version 83.38)
Entrez gene	341640
UniProt	Q5SZK8 (UniProt - Evidence at protein level)
neXtProt	NX_Q5SZK8
Antibodypedia	FREM2 antibodies

PROTEIN BROWSER

FREM2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FREM2-001 ENSP00000280481 ENST00000280481	Q5SZK8 [Direct mapping] FRAS1-related extracellular matrix protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0002009 [morphogenesis of an epithelium] GO:0005509 [calcium ion binding] GO:0005604 [basement membrane] GO:0005886 [plasma membrane] GO:0007154 [cell communication] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007507 [heart development] GO:0016021 [integral component of membrane] GO:0048839 [inner ear development] GO:0070062 [extracellular exosome] Show all	3169 aa 351.2 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.