Expression of PRSS53 in cancer - Summary - The Human Protein Atlas

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PRSS53

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PRSS53
Gene description	Protease, serine, 53
Protein class	Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (SCLC-21H)
HPA (normal tissue):	Tissue enhanced (skin)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA034955 , HPA034956
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA034955	HPA034956

GENE INFORMATION
Gene name	PRSS53 (HGNC Symbol)
Synonyms	POL3S
Description	Protease, serine, 53 (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	p11.2
Chromosome location (bp)	31083425 - 31089628
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000151006 (version 83.38)
Entrez gene	339105
UniProt	Q2L4Q9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q2L4Q9
Antibodypedia	PRSS53 antibodies

PROTEIN BROWSER

PRSS53-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRSS53-001 ENSP00000280606 ENST00000280606	Q2L4Q9 [Direct mapping] Serine protease 53 Show all	Enzymes Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] Show all	553 aa 58.4 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.