Fields »
ABOUT
HELP
BLOG
CACNA1C

GENERAL INFORMATION

Gene name

 CACNA1C

Gene description

 Calcium channel, voltage-dependent, L type, alpha 1C subunit

Protein class

 Disease related genes
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

 Intracellular,Membrane

Number of transcripts

 32
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (HDLM-2)
HPA (normal tissue):Tissue enhanced (smooth muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Membranous expression mainly in smooth muscle, endothelium and heart.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA039796
SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039796

GENE INFORMATION

Gene name

 CACNA1C (HGNC Symbol)

Synonyms

 CACH2, CACN2, CACNL1A1, Cav1.2, CCHL1A1, LQT8, TS

Description

 Calcium channel, voltage-dependent, L type, alpha 1C subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]

Chromosome

 12

Cytoband

 p13.33

Chromosome location (bp)

 1970786 - 2697950

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000151067 (version 83.38)

Entrez gene

 775

UniProt

 Q13936 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13936

Antibodypedia

 CACNA1C antibodies

PROTEIN BROWSER
«
CACNA1C-001
CACNA1C-002
CACNA1C-003
CACNA1C-004
CACNA1C-005
CACNA1C-006
CACNA1C-007
CACNA1C-008
CACNA1C-010
CACNA1C-011
CACNA1C-012
CACNA1C-013
CACNA1C-015
CACNA1C-016
CACNA1C-017
CACNA1C-018
CACNA1C-019
CACNA1C-020
CACNA1C-021
CACNA1C-022
CACNA1C-023
CACNA1C-024
CACNA1C-026
CACNA1C-031
CACNA1C-032
CACNA1C-034
CACNA1C-036
CACNA1C-201
CACNA1C-202
CACNA1C-203
CACNA1C-204
CACNA1C-205
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CACNA1C-001
ENSP00000382563
ENST00000399655
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
 2138 aa
239.6 kDa 		No >9
CACNA1C-002
ENSP00000382504
ENST00000399595
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
 2146 aa
240.4 kDa 		No >9
CACNA1C-003
ENSP00000382552
ENST00000399644
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
 2138 aa
239.5 kDa 		No >9
CACNA1C-004
ENSP00000382547
ENST00000399638
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
 2166 aa
242.8 kDa 		No >9
CACNA1C-005
ENSP00000382506
ENST00000399597
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
 2138 aa
239.7 kDa 		No >9
CACNA1C-006
ENSP00000382530
ENST00000399621
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
 2157 aa
241.6 kDa 		No >9
CACNA1C-007
ENSP00000382546
ENST00000399637
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
 2157 aa
241.5 kDa 		No >9
CACNA1C-008
ENSP00000382500
ENST00000399591
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
 2146 aa
240.3 kDa 		No >9
CACNA1C-010
ENSP00000382549
ENST00000399641
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
 2138 aa
239.5 kDa 		No >9
CACNA1C-011
ENSP00000382512
ENST00000399603
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
 2138 aa
239.7 kDa 		No >9
CACNA1C-012
ENSP00000382542
ENST00000399634
E9PDI6 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 2209 aa
247.1 kDa 		No >9
CACNA1C-013
ENSP00000382526
ENST00000399617
A0A0A0MSA1 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 2173 aa
243.7 kDa 		No >9
CACNA1C-015
ENSP00000336982
ENST00000335762
F5H522 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 2163 aa
242.4 kDa 		No >9
CACNA1C-016
ENSP00000478996
ENST00000465278
A0A087WUX4 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0034220 [ion transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 243 aa
27 kDa 		No 2
CACNA1C-017
ENSP00000266376
ENST00000347598
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0002095 [caveolar macromolecular signaling complex]
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006939 [smooth muscle contraction]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007628 [adult walking behavior]
GO:0008217 [regulation of blood pressure]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0008542 [visual learning]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017156 [calcium ion-dependent exocytosis]
GO:0019229 [regulation of vasoconstriction]
GO:0030018 [Z disc]
GO:0030073 [insulin secretion]
GO:0030252 [growth hormone secretion]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0042593 [glucose homeostasis]
GO:0043025 [neuronal cell body]
GO:0043198 [dendritic shaft]
GO:0044281 [small molecule metabolic process]
GO:0046620 [regulation of organ growth]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060083 [smooth muscle contraction involved in micturition]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
 2186 aa
245 kDa 		No >9
CACNA1C-018
ENSP00000437936
ENST00000480911
F5H638 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 1279 aa
144.7 kDa 		No >9
CACNA1C-019
ENSP00000382515
ENST00000399606
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
 2158 aa
241.9 kDa 		No >9
CACNA1C-020
ENSP00000382510
ENST00000399601
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
 2138 aa
239.5 kDa 		No >9
CACNA1C-021
ENSP00000341092
ENST00000344100
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
 2179 aa
243.7 kDa 		No >9
CACNA1C-022
ENSP00000382537
ENST00000399629
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
 2155 aa
241.5 kDa 		No >9
CACNA1C-023
ENSP00000329877
ENST00000327702
A0A0A0MR67 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 2173 aa
243.5 kDa 		No >9
CACNA1C-024
ENSP00000382557
ENST00000399649
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
 2144 aa
240.2 kDa 		No >9
CACNA1C-026
ENSP00000479274
ENST00000496818
A0A087WV93 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0034220 [ion transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 144 aa
17.3 kDa 		No 2
CACNA1C-031
ENSP00000385896
ENST00000406454
F5GY28 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 2209 aa
247.2 kDa 		No >9
CACNA1C-032
ENSP00000385724
ENST00000402845
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
 2157 aa
241.6 kDa 		No >9
CACNA1C-034
ENSP00000445849
ENST00000543114
F5H0X0 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted intracellular proteins
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0034220 [ion transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 100 aa
10.4 kDa 		No 0
CACNA1C-036
ENSP00000482910
ENST00000616390
A0A087WZV3 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 829 aa
91.5 kDa 		No 3
CACNA1C-201
ENSP00000483335
ENST00000613940
A0A087X0E8 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 2014 aa
226.5 kDa 		No >9
CACNA1C-202
ENSP00000480922
ENST00000615303
A0A087WXD3 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 2062 aa
231.8 kDa 		No >9
CACNA1C-203
ENSP00000480292
ENST00000615400
A0A087WWK5 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 2027 aa
227.9 kDa 		No >9
CACNA1C-204
ENSP00000479029
ENST00000620878
A0A087WUZ0 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 2039 aa
228.8 kDa 		No >9
CACNA1C-205
ENSP00000484796
ENST00000621625
A0A087X293 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 2014 aa
226.3 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.