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ANK3

GENERAL INFORMATION

Gene name

 ANK3

Gene description

 Ankyrin 3, node of Ranvier (ankyrin G)

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 25
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Mainly membranous expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA055643 , CAB013249 , CAB015179
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Epididymis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ANK3

Synonyms

Description

 Ankyrin 3, node of Ranvier (ankyrin G) (HGNC Symbol)

Entrez gene summary

 Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

Chromosome

 10

Cytoband

 q21.2

Chromosome location (bp)

 60026298 - 60733490

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000151150 (version 83.38)

Entrez gene

 288

UniProt

 Q12955 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12955

Antibodypedia

 ANK3 antibodies

PROTEIN BROWSER
«
ANK3-001
ANK3-002
ANK3-003
ANK3-004
ANK3-005
ANK3-006
ANK3-007
ANK3-008
ANK3-009
ANK3-010
ANK3-011
ANK3-012
ANK3-013
ANK3-014
ANK3-017
ANK3-021
ANK3-023
ANK3-029
ANK3-030
ANK3-031
ANK3-032
ANK3-033
ANK3-034
ANK3-035
ANK3-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ANK3-001
ENSP00000280772
ENST00000280772
Q12955 [Direct mapping]
Ankyrin-3
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005923 [bicellular tight junction]
GO:0007009 [plasma membrane organization]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0007165 [signal transduction]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0008092 [cytoskeletal protein binding]
GO:0009925 [basal plasma membrane]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010765 [positive regulation of sodium ion transport]
GO:0010960 [magnesium ion homeostasis]
GO:0014704 [intercalated disc]
GO:0014731 [spectrin-associated cytoskeleton]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0019228 [neuronal action potential]
GO:0030315 [T-tubule]
GO:0030424 [axon]
GO:0030507 [spectrin binding]
GO:0030674 [protein binding, bridging]
GO:0033268 [node of Ranvier]
GO:0033270 [paranode region of axon]
GO:0042383 [sarcolemma]
GO:0043001 [Golgi to plasma membrane protein transport]
GO:0043034 [costamere]
GO:0043194 [axon initial segment]
GO:0043266 [regulation of potassium ion transport]
GO:0044325 [ion channel binding]
GO:0045184 [establishment of protein localization]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045296 [cadherin binding]
GO:0045838 [positive regulation of membrane potential]
GO:0050808 [synapse organization]
GO:0071286 [cellular response to magnesium ion]
GO:0071709 [membrane assembly]
GO:0072659 [protein localization to plasma membrane]
GO:0072660 [maintenance of protein location in plasma membrane]
GO:0072661 [protein targeting to plasma membrane]
GO:1900827 [positive regulation of membrane depolarization during cardiac muscle cell action potential]
GO:1902260 [negative regulation of delayed rectifier potassium channel activity]
GO:2000651 [positive regulation of sodium ion transmembrane transporter activity]
Show all
 4377 aa
480.4 kDa 		No 0
ANK3-002
ENSP00000347436
ENST00000355288
Q12955 [Direct mapping]
Ankyrin-3
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005923 [bicellular tight junction]
GO:0007009 [plasma membrane organization]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0007165 [signal transduction]
GO:0007409 [axonogenesis]
GO:0008092 [cytoskeletal protein binding]
GO:0009925 [basal plasma membrane]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010765 [positive regulation of sodium ion transport]
GO:0010960 [magnesium ion homeostasis]
GO:0014704 [intercalated disc]
GO:0014731 [spectrin-associated cytoskeleton]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0019228 [neuronal action potential]
GO:0030315 [T-tubule]
GO:0030507 [spectrin binding]
GO:0030674 [protein binding, bridging]
GO:0033268 [node of Ranvier]
GO:0042383 [sarcolemma]
GO:0043001 [Golgi to plasma membrane protein transport]
GO:0043034 [costamere]
GO:0043194 [axon initial segment]
GO:0043266 [regulation of potassium ion transport]
GO:0044325 [ion channel binding]
GO:0045184 [establishment of protein localization]
GO:0045211 [postsynaptic membrane]
GO:0045296 [cadherin binding]
GO:0045838 [positive regulation of membrane potential]
GO:0071286 [cellular response to magnesium ion]
GO:0071709 [membrane assembly]
GO:0072659 [protein localization to plasma membrane]
GO:0072660 [maintenance of protein location in plasma membrane]
GO:0072661 [protein targeting to plasma membrane]
GO:1900827 [positive regulation of membrane depolarization during cardiac muscle cell action potential]
GO:1902260 [negative regulation of delayed rectifier potassium channel activity]
GO:2000651 [positive regulation of sodium ion transmembrane transporter activity]
Show all
 1001 aa
111.1 kDa 		No 0
ANK3-003
ENSP00000423968
ENST00000467420
H0Y9E9 [Direct mapping]
Ankyrin-3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
 196 aa
21.7 kDa 		No 0
ANK3-004
ENSP00000362933
ENST00000373827
Q12955 [Direct mapping]
Ankyrin-3
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005923 [bicellular tight junction]
GO:0007009 [plasma membrane organization]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0007165 [signal transduction]
GO:0007409 [axonogenesis]
GO:0008092 [cytoskeletal protein binding]
GO:0009925 [basal plasma membrane]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010765 [positive regulation of sodium ion transport]
GO:0010960 [magnesium ion homeostasis]
GO:0014704 [intercalated disc]
GO:0014731 [spectrin-associated cytoskeleton]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0019228 [neuronal action potential]
GO:0030315 [T-tubule]
GO:0030507 [spectrin binding]
GO:0030674 [protein binding, bridging]
GO:0033268 [node of Ranvier]
GO:0042383 [sarcolemma]
GO:0043001 [Golgi to plasma membrane protein transport]
GO:0043034 [costamere]
GO:0043194 [axon initial segment]
GO:0043266 [regulation of potassium ion transport]
GO:0044325 [ion channel binding]
GO:0045184 [establishment of protein localization]
GO:0045211 [postsynaptic membrane]
GO:0045296 [cadherin binding]
GO:0045838 [positive regulation of membrane potential]
GO:0071286 [cellular response to magnesium ion]
GO:0071709 [membrane assembly]
GO:0072659 [protein localization to plasma membrane]
GO:0072660 [maintenance of protein location in plasma membrane]
GO:0072661 [protein targeting to plasma membrane]
GO:1900827 [positive regulation of membrane depolarization during cardiac muscle cell action potential]
GO:1902260 [negative regulation of delayed rectifier potassium channel activity]
GO:2000651 [positive regulation of sodium ion transmembrane transporter activity]
Show all
 1861 aa
202.6 kDa 		No 0
ANK3-005
ENSP00000425236
ENST00000503366
Q12955 [Direct mapping]
Ankyrin-3
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005923 [bicellular tight junction]
GO:0007009 [plasma membrane organization]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0007165 [signal transduction]
GO:0007409 [axonogenesis]
GO:0008092 [cytoskeletal protein binding]
GO:0009925 [basal plasma membrane]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010765 [positive regulation of sodium ion transport]
GO:0010960 [magnesium ion homeostasis]
GO:0014704 [intercalated disc]
GO:0014731 [spectrin-associated cytoskeleton]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0019228 [neuronal action potential]
GO:0030315 [T-tubule]
GO:0030507 [spectrin binding]
GO:0030674 [protein binding, bridging]
GO:0033268 [node of Ranvier]
GO:0042383 [sarcolemma]
GO:0043001 [Golgi to plasma membrane protein transport]
GO:0043034 [costamere]
GO:0043194 [axon initial segment]
GO:0043266 [regulation of potassium ion transport]
GO:0044325 [ion channel binding]
GO:0045184 [establishment of protein localization]
GO:0045211 [postsynaptic membrane]
GO:0045296 [cadherin binding]
GO:0045838 [positive regulation of membrane potential]
GO:0071286 [cellular response to magnesium ion]
GO:0071709 [membrane assembly]
GO:0072659 [protein localization to plasma membrane]
GO:0072660 [maintenance of protein location in plasma membrane]
GO:0072661 [protein targeting to plasma membrane]
GO:1900827 [positive regulation of membrane depolarization during cardiac muscle cell action potential]
GO:1902260 [negative regulation of delayed rectifier potassium channel activity]
GO:2000651 [positive regulation of sodium ion transmembrane transporter activity]
Show all
 1868 aa
204.1 kDa 		No 0
ANK3-006
ENSP00000422657
ENST00000474360
H0Y8Z4 [Direct mapping]
Ankyrin-3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
 114 aa
12.8 kDa 		No 0
ANK3-007
ENSP00000426690
ENST00000460468
D6RF31 [Direct mapping]
Ankyrin-3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
 86 aa
9.6 kDa 		No 0
ANK3-008
ENSP00000362921
ENST00000373815
B1AQT1 [Direct mapping]
Ankyrin-3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
 195 aa
21.5 kDa 		No 0
ANK3-009
ENSP00000362926
ENST00000373820
H0Y3A4 [Direct mapping]
Ankyrin-3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
Show all
 459 aa
50.7 kDa 		No 0
ANK3-010
ENSP00000426011
ENST00000503925
D6RHY3 [Direct mapping]
Ankyrin-3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 273 aa
29.1 kDa 		No 0
ANK3-011
ENSP00000423057
ENST00000502769
H0Y951 [Direct mapping]
Ankyrin-3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
 166 aa
18.1 kDa 		No 0
ANK3-012
ENSP00000422506
ENST00000506635
D6RBY7 [Direct mapping]
Ankyrin-3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
 72 aa
8 kDa 		No 0
ANK3-013
ENSP00000426582
ENST00000513049
D6RFK6 [Direct mapping]
Ankyrin-3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
 159 aa
17.8 kDa 		No 0
ANK3-014
ENSP00000427121
ENST00000514197
H0YAH5 [Direct mapping]
Ankyrin-3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
Show all
 217 aa
23.7 kDa 		No 0
ANK3-017
ENSP00000483483
ENST00000486349
A0A087X0L3 [Direct mapping]
Ankyrin-3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
 63 aa
6.7 kDa 		No 0
ANK3-021
ENSP00000480249
ENST00000459732
A0A087WWI5 [Direct mapping]
Ankyrin-3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
Show all
 96 aa
10.7 kDa 		No 0
ANK3-023
ENSP00000426258
ENST00000511043
H0YA66 [Direct mapping]
Ankyrin-3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
Show all
 188 aa
20.9 kDa 		No 0
ANK3-029
ENSP00000479337
ENST00000610901
A0A087WVC2 [Direct mapping]
Ankyrin-3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
Show all
 322 aa
36 kDa 		No 0
ANK3-030
ENSP00000477814
ENST00000613207
A0A087WTE8 [Direct mapping]
Ankyrin-3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
Show all
 241 aa
26.9 kDa 		No 0
ANK3-031
ENSP00000480745
ENST00000617800
A0A087WX55 [Direct mapping]
Ankyrin-3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
 175 aa
19.7 kDa 		No 0
ANK3-032
ENSP00000481611
ENST00000612776
A0A087WY90 [Direct mapping]
Ankyrin-3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
 178 aa
19.4 kDa 		No 0
ANK3-033
ENSP00000482401
ENST00000616444
A0A087WZ65 [Direct mapping]
Ankyrin-3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
Show all
 973 aa
108.6 kDa 		No 0
ANK3-034
ENSP00000477827
ENST00000610321
A0A087WTF3 [Direct mapping]
Ankyrin-3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
Show all
 1643 aa
179.5 kDa 		No 0
ANK3-035
ENSP00000482307
ENST00000618080
A0A087WZ26 [Direct mapping]
Ankyrin-3
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
 202 aa
22.2 kDa 		No 0
ANK3-201
ENSP00000479018
ENST00000618374
A0A087WUY3 [Direct mapping]
Ankyrin-3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
Show all
 811 aa
90.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.