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MAT1A

GENERAL INFORMATION

Gene name

 MAT1A

Gene description

 Methionine adenosyltransferase I, alpha

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enriched (Hep G2)
HPA (normal tissue):Tissue enriched (liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in liver.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. External characterization data supports antibody staining.

Reliability score

 Supported based on 1 antibody.
HPA048627
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA048627

GENE INFORMATION

Gene name

 MAT1A (HGNC Symbol)

Synonyms

 MAT, MATA1, SAMS, SAMS1

Description

 Methionine adenosyltransferase I, alpha (HGNC Symbol)

Entrez gene summary

 This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q22.3

Chromosome location (bp)

 80271820 - 80289684

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000151224 (version 83.38)

Entrez gene

 4143

UniProt

 Q00266 (UniProt - Evidence at protein level)

neXtProt

 NX_Q00266

Antibodypedia

 MAT1A antibodies

PROTEIN BROWSER
MAT1A-001
MAT1A-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAT1A-001
ENSP00000361287
ENST00000372213
Q00266 [Direct mapping]
S-adenosylmethionine synthase isoform type-1
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000096 [sulfur amino acid metabolic process]
GO:0004478 [methionine adenosyltransferase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006520 [cellular amino acid metabolic process]
GO:0006556 [S-adenosylmethionine biosynthetic process]
GO:0006730 [one-carbon metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0032259 [methylation]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
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 395 aa
43.6 kDa 		No 0
MAT1A-002
ENSP00000414961
ENST00000455001
B1ANE6 [Direct mapping]
S-adenosylmethionine synthase isoform type-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004478 [methionine adenosyltransferase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006556 [S-adenosylmethionine biosynthetic process]
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 145 aa
16 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.