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MAGI1

GENERAL INFORMATION

Gene name

 MAGI1

Gene description

 Membrane associated guanylate kinase, WW and PDZ domain containing 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HEL)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in several different tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA031853
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Endometrial cancer

STAINING SUMMARY
HPA031853

GENE INFORMATION

Gene name

 MAGI1 (HGNC Symbol)

Synonyms

 AIP3, BAIAP1, BAP1, MAGI-1, TNRC19, WWP3

Description

 Membrane associated guanylate kinase, WW and PDZ domain containing 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p14.1

Chromosome location (bp)

 65353525 - 66038834

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000151276 (version 83.38)

Entrez gene

 9223

UniProt

 Q96QZ7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96QZ7

Antibodypedia

 MAGI1 antibodies

PROTEIN BROWSER
MAGI1-001
MAGI1-002
MAGI1-003
MAGI1-004
MAGI1-007
MAGI1-008
MAGI1-010
MAGI1-015
MAGI1-201
MAGI1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAGI1-001
ENSP00000385450
ENST00000402939
Q96QZ7 [Direct mapping]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005923 [bicellular tight junction]
GO:0006461 [protein complex assembly]
GO:0007155 [cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0030054 [cell junction]
GO:0032947 [protein complex scaffold]
GO:0042995 [cell projection]
GO:0051393 [alpha-actinin binding]
GO:0070997 [neuron death]
Show all
 1462 aa
161.5 kDa 		No 0
MAGI1-002
ENSP00000331157
ENST00000330909
Q96QZ7 [Direct mapping]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005923 [bicellular tight junction]
GO:0006461 [protein complex assembly]
GO:0007155 [cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0030054 [cell junction]
GO:0032947 [protein complex scaffold]
GO:0042995 [cell projection]
GO:0051393 [alpha-actinin binding]
GO:0070997 [neuron death]
Show all
 1287 aa
140.4 kDa 		No 0
MAGI1-003
ENSP00000420323
ENST00000483466
Q96QZ7 [Direct mapping]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005923 [bicellular tight junction]
GO:0006461 [protein complex assembly]
GO:0007155 [cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0030054 [cell junction]
GO:0032947 [protein complex scaffold]
GO:0042995 [cell projection]
GO:0051393 [alpha-actinin binding]
GO:0070997 [neuron death]
Show all
 1256 aa
136.9 kDa 		No 0
MAGI1-004
ENSP00000420796
ENST00000472257
H7C5T8 [Direct mapping]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005923 [bicellular tight junction]
GO:0030054 [cell junction]
GO:0032947 [protein complex scaffold]
Show all
 1014 aa
110.8 kDa 		No 0
MAGI1-007
ENSP00000424369
ENST00000497477
Q96QZ7 [Direct mapping]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005923 [bicellular tight junction]
GO:0006461 [protein complex assembly]
GO:0007155 [cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0030054 [cell junction]
GO:0032947 [protein complex scaffold]
GO:0042995 [cell projection]
GO:0051393 [alpha-actinin binding]
GO:0070997 [neuron death]
Show all
 1160 aa
126.9 kDa 		No 0
MAGI1-008
ENSP00000418862
ENST00000460329
H7C535 [Direct mapping]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005923 [bicellular tight junction]
GO:0032947 [protein complex scaffold]
Show all
 1136 aa
123.7 kDa 		No 0
MAGI1-010
ENSP00000418177
ENST00000463103
H7C4U7 [Direct mapping]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005923 [bicellular tight junction]
GO:0030054 [cell junction]
GO:0032947 [protein complex scaffold]
Show all
 1131 aa
123.1 kDa 		No 0
MAGI1-015
ENSP00000418044
ENST00000479287
H7C4S7 [Direct mapping]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005923 [bicellular tight junction]
GO:0032947 [protein complex scaffold]
Show all
 185 aa
21.5 kDa 		No 0
MAGI1-201
ENSP00000480920
ENST00000611645
A0A087WXD2 [Direct mapping]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005923 [bicellular tight junction]
GO:0032947 [protein complex scaffold]
Show all
 980 aa
106.9 kDa 		No 0
MAGI1-202
ENSP00000477591
ENST00000621418
A0A087WT53 [Direct mapping]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005923 [bicellular tight junction]
GO:0032947 [protein complex scaffold]
Show all
 1155 aa
128.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.