Expression of SRFBP1 in cancer - Summary - The Human Protein Atlas

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SRFBP1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SRFBP1
Gene description	Serum response factor binding protein 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA042737
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042737

GENE INFORMATION
Gene name	SRFBP1 (HGNC Symbol)
Synonyms	BUD22, FLJ25286, p49, Rlb1, STRAP
Description	Serum response factor binding protein 1 (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	q23.1
Chromosome location (bp)	121961961 - 122075570
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151304 (version 83.38)
Entrez gene	153443
UniProt	Q8NEF9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NEF9
Antibodypedia	SRFBP1 antibodies

PROTEIN BROWSER

SRFBP1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SRFBP1-001 ENSP00000341324 ENST00000339397	Q8NEF9 [Direct mapping] Serum response factor-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0030490 [maturation of SSU-rRNA] GO:0030686 [90S preribosome] GO:0044822 [poly(A) RNA binding] GO:0048471 [perinuclear region of cytoplasm] Show all	429 aa 48.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.