Expression of MBIP in cancer - Summary - The Human Protein Atlas

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MBIP

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MBIP
Gene description	MAP3K12 binding inhibitory protein 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression. Additional cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA003388
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (favourable), renal cancer (favourable) and lung cancer (favourable).
Ovarian cancer p<0.001 Renal cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003388

GENE INFORMATION
Gene name	MBIP
Synonyms
Description	MAP3K12 binding inhibitory protein 1 (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q13.3
Chromosome location (bp)	36298558 - 36320676
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151332 (version 83.38)
Entrez gene	51562
UniProt	Q9NS73 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NS73
Antibodypedia	MBIP antibodies

PROTEIN BROWSER

MBIP-001	MBIP-003	MBIP-004	MBIP-005	MBIP-006	MBIP-008	MBIP-010	MBIP-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MBIP-001 ENSP00000399718 ENST00000416007	Q9NS73 [Direct mapping] MAP3K12-binding inhibitory protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000173 [inactivation of MAPK activity involved in osmosensory signaling pathway] GO:0004860 [protein kinase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006325 [chromatin organization] GO:0042802 [identical protein binding] GO:0043966 [histone H3 acetylation] GO:1904030 [negative regulation of cyclin-dependent protein kinase activity] Show all	344 aa 39.3 kDa	No	0
MBIP-003 ENSP00000352517 ENST00000359527	Q9NS73 [Direct mapping] MAP3K12-binding inhibitory protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000173 [inactivation of MAPK activity involved in osmosensory signaling pathway] GO:0004860 [protein kinase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006325 [chromatin organization] GO:0042802 [identical protein binding] GO:0043966 [histone H3 acetylation] GO:1904030 [negative regulation of cyclin-dependent protein kinase activity] Show all	282 aa 32.2 kDa	No	0
MBIP-004 ENSP00000324444 ENST00000318473	Q9NS73 [Direct mapping] MAP3K12-binding inhibitory protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000173 [inactivation of MAPK activity involved in osmosensory signaling pathway] GO:0004860 [protein kinase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006325 [chromatin organization] GO:0042802 [identical protein binding] GO:0043966 [histone H3 acetylation] GO:1904030 [negative regulation of cyclin-dependent protein kinase activity] Show all	343 aa 39.2 kDa	No	0
MBIP-005 ENSP00000474845 ENST00000604160	S4R3Y0 [Direct mapping] MAP3K12-binding inhibitory protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		113 aa 13 kDa	No	0
MBIP-006 ENSP00000474583 ENST00000603139	S4R3P6 [Direct mapping] MAP3K12-binding inhibitory protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		222 aa 25.3 kDa	No	0
MBIP-008 ENSP00000474535 ENST00000604336	S4R3N2 [Direct mapping] MAP3K12-binding inhibitory protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		281 aa 32.1 kDa	No	0
MBIP-010 ENSP00000473739 ENST00000605579	S4R2X9 [Direct mapping] MAP3K12-binding inhibitory protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		299 aa 34.1 kDa	No	0
MBIP-201 ENSP00000484282 ENST00000621657	A0A087X1L0 [Direct mapping] MAP3K12-binding inhibitory protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		298 aa 34 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.