Cell atlas - EXT2 - The Human Protein Atlas

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EXT2

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus

Human cell
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	EXT2
Gene description	Exostosin glycosyltransferase 2
Protein class	Cancer-related genes Disease related genes Enzymes Plasma proteins Potential drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA078409
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus.

Main location

Golgi apparatus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA078409	SiHa	Golgi apparatus

GENE INFORMATION
Gene name	EXT2 (HGNC Symbol)
Synonyms	SOTV
Description	Exostosin glycosyltransferase 2 (HGNC Symbol)
Entrez gene summary	This gene encodes one of two glycosyltransferases involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type II form of multiple exostoses. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	p11.2
Chromosome location (bp)	44095549 - 44245429
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151348 (version 83.38)
Entrez gene	2132
UniProt	Q93063 (UniProt - Evidence at protein level)
neXtProt	NX_Q93063
Antibodypedia	EXT2 antibodies

PROTEIN BROWSER

EXT2-001	EXT2-002	EXT2-005	EXT2-006	EXT2-007	EXT2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EXT2-001 ENSP00000431173 ENST00000533608	Q93063 [Direct mapping] Exostosin-2 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001503 [ossification] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0006486 [protein glycosylation] GO:0007165 [signal transduction] GO:0008375 [acetylglucosaminyltransferase activity] GO:0015012 [heparan sulfate proteoglycan biosynthetic process] GO:0015014 [heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process] GO:0015020 [glucuronosyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016757 [transferase activity, transferring glycosyl groups] GO:0030203 [glycosaminoglycan metabolic process] GO:0033692 [cellular polysaccharide biosynthetic process] GO:0042328 [heparan sulfate N-acetylglucosaminyltransferase activity] GO:0043541 [UDP-N-acetylglucosamine transferase complex] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0050508 [glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity] GO:0050509 [N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity] GO:0070062 [extracellular exosome] Show all	718 aa 82.3 kDa	No	1
EXT2-002 ENSP00000351509 ENST00000358681	Q93063 [Direct mapping] Exostosin-2 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001503 [ossification] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0006486 [protein glycosylation] GO:0007165 [signal transduction] GO:0008375 [acetylglucosaminyltransferase activity] GO:0015012 [heparan sulfate proteoglycan biosynthetic process] GO:0015014 [heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process] GO:0015020 [glucuronosyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016757 [transferase activity, transferring glycosyl groups] GO:0030203 [glycosaminoglycan metabolic process] GO:0033692 [cellular polysaccharide biosynthetic process] GO:0042328 [heparan sulfate N-acetylglucosaminyltransferase activity] GO:0043541 [UDP-N-acetylglucosamine transferase complex] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0050508 [glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity] GO:0050509 [N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity] GO:0070062 [extracellular exosome] Show all	728 aa 83.6 kDa	No	1
EXT2-005 ENSP00000342656 ENST00000343631	Q93063 [Direct mapping] Exostosin-2 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001503 [ossification] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0006486 [protein glycosylation] GO:0007165 [signal transduction] GO:0008375 [acetylglucosaminyltransferase activity] GO:0015012 [heparan sulfate proteoglycan biosynthetic process] GO:0015014 [heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process] GO:0015020 [glucuronosyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016757 [transferase activity, transferring glycosyl groups] GO:0030203 [glycosaminoglycan metabolic process] GO:0033692 [cellular polysaccharide biosynthetic process] GO:0042328 [heparan sulfate N-acetylglucosaminyltransferase activity] GO:0043541 [UDP-N-acetylglucosamine transferase complex] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0050508 [glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity] GO:0050509 [N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity] GO:0070062 [extracellular exosome] Show all	718 aa 82.3 kDa	No	1
EXT2-006 ENSP00000433827 ENST00000532479	E9PJA5 [Direct mapping] Exostosin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	49 aa 5.7 kDa	No	1
EXT2-007 ENSP00000434716 ENST00000527014	E9PNL9 [Direct mapping] Exostosin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	112 aa 13 kDa	No	1
EXT2-201 ENSP00000379032 ENST00000395673	Q93063 [Direct mapping] Exostosin-2 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001503 [ossification] GO:0001707 [mesoderm formation] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0006486 [protein glycosylation] GO:0007165 [signal transduction] GO:0008375 [acetylglucosaminyltransferase activity] GO:0015012 [heparan sulfate proteoglycan biosynthetic process] GO:0015014 [heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process] GO:0015020 [glucuronosyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016757 [transferase activity, transferring glycosyl groups] GO:0030154 [cell differentiation] GO:0030203 [glycosaminoglycan metabolic process] GO:0033692 [cellular polysaccharide biosynthetic process] GO:0042328 [heparan sulfate N-acetylglucosaminyltransferase activity] GO:0042803 [protein homodimerization activity] GO:0043541 [UDP-N-acetylglucosamine transferase complex] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0050508 [glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity] GO:0050509 [N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity] GO:0070062 [extracellular exosome] Show all	751 aa 85.8 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.