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ATP6V1G3

GENERAL INFORMATION

Gene name

 ATP6V1G3

Gene description

 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3

Protein class

 Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (kidney)
GTEx:Tissue enriched (kidney)
FANTOM5:Tissue enriched (kidney)

Protein evidence

 Evidence at protein level

Protein expression

 Expression in a subset of cells in distal tubule in kidney.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA028701
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)

GENE INFORMATION

Gene name

 ATP6V1G3 (HGNC Symbol)

Synonyms

 ATP6G3, Vma10

Description

 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'' and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three G subunit proteins. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q31.3

Chromosome location (bp)

 198523222 - 198540945

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000151418 (version 83.38)

Entrez gene

 127124

UniProt

 Q96LB4 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q96LB4

Antibodypedia

 ATP6V1G3 antibodies

PROTEIN BROWSER
ATP6V1G3-001
ATP6V1G3-002
ATP6V1G3-003
ATP6V1G3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP6V1G3-001
ENSP00000356352
ENST00000367382
Q96LB4 [Direct mapping]
V-type proton ATPase subunit G 3
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006879 [cellular iron ion homeostasis]
GO:0008286 [insulin receptor signaling pathway]
GO:0015992 [proton transport]
GO:0016471 [vacuolar proton-transporting V-type ATPase complex]
GO:0016820 [hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances]
GO:0033572 [transferrin transport]
GO:0034220 [ion transmembrane transport]
GO:0051117 [ATPase binding]
GO:0055085 [transmembrane transport]
GO:0090382 [phagosome maturation]
Show all
 118 aa
13.9 kDa 		No 0
ATP6V1G3-002
ENSP00000309574
ENST00000309309
Q96LB4 [Direct mapping]
V-type proton ATPase subunit G 3
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006879 [cellular iron ion homeostasis]
GO:0008286 [insulin receptor signaling pathway]
GO:0016471 [vacuolar proton-transporting V-type ATPase complex]
GO:0033572 [transferrin transport]
GO:0034220 [ion transmembrane transport]
GO:0051117 [ATPase binding]
GO:0055085 [transmembrane transport]
GO:0090382 [phagosome maturation]
Show all
 59 aa
6.9 kDa 		No 0
ATP6V1G3-003
ENSP00000417171
ENST00000489986
Q96LB4 [Direct mapping]
V-type proton ATPase subunit G 3
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006879 [cellular iron ion homeostasis]
GO:0008286 [insulin receptor signaling pathway]
GO:0015992 [proton transport]
GO:0016471 [vacuolar proton-transporting V-type ATPase complex]
GO:0016820 [hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances]
GO:0033572 [transferrin transport]
GO:0034220 [ion transmembrane transport]
GO:0051117 [ATPase binding]
GO:0055085 [transmembrane transport]
GO:0090382 [phagosome maturation]
Show all
 124 aa
14.4 kDa 		No 0
ATP6V1G3-201
ENSP00000281087
ENST00000281087
Q96LB4 [Direct mapping]
V-type proton ATPase subunit G 3
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006879 [cellular iron ion homeostasis]
GO:0008286 [insulin receptor signaling pathway]
GO:0008553 [hydrogen-exporting ATPase activity, phosphorylative mechanism]
GO:0015992 [proton transport]
GO:0016471 [vacuolar proton-transporting V-type ATPase complex]
GO:0016820 [hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances]
GO:0033572 [transferrin transport]
GO:0034220 [ion transmembrane transport]
GO:0051117 [ATPase binding]
GO:0055085 [transmembrane transport]
GO:0090382 [phagosome maturation]
Show all
 118 aa
13.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.