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EPS8

GENERAL INFORMATION

Gene name

 EPS8

Gene description

 Epidermal growth factor receptor pathway substrate 8

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (WM-115)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA003897
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), pancreatic cancer (unfavourable) and thyroid cancer (favourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
Thyroid cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003897

GENE INFORMATION

Gene name

 EPS8

Synonyms

Description

 Epidermal growth factor receptor pathway substrate 8 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 p12.3

Chromosome location (bp)

 15620158 - 15882329

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000151491 (version 83.38)

Entrez gene

 2059

UniProt

 Q12929 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12929

Antibodypedia

 EPS8 antibodies

PROTEIN BROWSER
EPS8-001
EPS8-003
EPS8-004
EPS8-005
EPS8-006
EPS8-007
EPS8-008
EPS8-009
EPS8-010
EPS8-017

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EPS8-001
ENSP00000281172
ENST00000281172
Q12929 [Direct mapping]
Epidermal growth factor receptor kinase substrate 8
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005903 [brush border]
GO:0005938 [cell cortex]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008283 [cell proliferation]
GO:0008344 [adult locomotory behavior]
GO:0008360 [regulation of cell shape]
GO:0009967 [positive regulation of signal transduction]
GO:0010458 [exit from mitosis]
GO:0014069 [postsynaptic density]
GO:0016601 [Rac protein signal transduction]
GO:0017146 [NMDA selective glutamate receptor complex]
GO:0030054 [cell junction]
GO:0030426 [growth cone]
GO:0030832 [regulation of actin filament length]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031982 [vesicle]
GO:0032420 [stereocilium]
GO:0032587 [ruffle membrane]
GO:0036336 [dendritic cell migration]
GO:0045202 [synapse]
GO:0048149 [behavioral response to ethanol]
GO:0048365 [Rac GTPase binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
GO:0070062 [extracellular exosome]
GO:0070358 [actin polymerization-dependent cell motility]
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 822 aa
91.9 kDa 		No 0
EPS8-003
ENSP00000441867
ENST00000543523
Q12929 [Direct mapping]
Epidermal growth factor receptor kinase substrate 8
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005938 [cell cortex]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008283 [cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009967 [positive regulation of signal transduction]
GO:0010458 [exit from mitosis]
GO:0016601 [Rac protein signal transduction]
GO:0030054 [cell junction]
GO:0030426 [growth cone]
GO:0030832 [regulation of actin filament length]
GO:0031982 [vesicle]
GO:0032420 [stereocilium]
GO:0032587 [ruffle membrane]
GO:0036336 [dendritic cell migration]
GO:0048365 [Rac GTPase binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
GO:0070062 [extracellular exosome]
GO:0070358 [actin polymerization-dependent cell motility]
Show all
 822 aa
91.9 kDa 		No 0
EPS8-004
ENSP00000442388
ENST00000543612
Q12929 [Direct mapping]
Epidermal growth factor receptor kinase substrate 8
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005938 [cell cortex]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008283 [cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009967 [positive regulation of signal transduction]
GO:0010458 [exit from mitosis]
GO:0016601 [Rac protein signal transduction]
GO:0030054 [cell junction]
GO:0030426 [growth cone]
GO:0030832 [regulation of actin filament length]
GO:0031982 [vesicle]
GO:0032420 [stereocilium]
GO:0032587 [ruffle membrane]
GO:0036336 [dendritic cell migration]
GO:0048365 [Rac GTPase binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
GO:0070062 [extracellular exosome]
GO:0070358 [actin polymerization-dependent cell motility]
Show all
 822 aa
91.9 kDa 		No 0
EPS8-005
ENSP00000441888
ENST00000540613
Q12929 [Direct mapping]
Epidermal growth factor receptor kinase substrate 8
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005938 [cell cortex]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008283 [cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009967 [positive regulation of signal transduction]
GO:0010458 [exit from mitosis]
GO:0016601 [Rac protein signal transduction]
GO:0030054 [cell junction]
GO:0030426 [growth cone]
GO:0030832 [regulation of actin filament length]
GO:0031982 [vesicle]
GO:0032420 [stereocilium]
GO:0032587 [ruffle membrane]
GO:0036336 [dendritic cell migration]
GO:0048365 [Rac GTPase binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
GO:0070062 [extracellular exosome]
GO:0070358 [actin polymerization-dependent cell motility]
Show all
 562 aa
62.9 kDa 		No 0
EPS8-006
ENSP00000437806
ENST00000542903
Q12929 [Direct mapping]
Epidermal growth factor receptor kinase substrate 8
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005938 [cell cortex]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008283 [cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009967 [positive regulation of signal transduction]
GO:0010458 [exit from mitosis]
GO:0016601 [Rac protein signal transduction]
GO:0030054 [cell junction]
GO:0030426 [growth cone]
GO:0030832 [regulation of actin filament length]
GO:0031982 [vesicle]
GO:0032420 [stereocilium]
GO:0032587 [ruffle membrane]
GO:0036336 [dendritic cell migration]
GO:0048365 [Rac GTPase binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051017 [actin filament bundle assembly]
GO:0051764 [actin crosslink formation]
GO:0070062 [extracellular exosome]
GO:0070358 [actin polymerization-dependent cell motility]
Show all
 562 aa
62.9 kDa 		No 0
EPS8-007
ENSP00000444613
ENST00000543363
F5H2B8 [Direct mapping]
Epidermal growth factor receptor kinase substrate 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0009967 [positive regulation of signal transduction]
GO:0035591 [signaling adaptor activity]
GO:0051016 [barbed-end actin filament capping]
GO:0051017 [actin filament bundle assembly]
Show all
 68 aa
7.6 kDa 		No 0
EPS8-008
ENSP00000445235
ENST00000546311
F5H3Q6 [Direct mapping]
Epidermal growth factor receptor kinase substrate 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0009967 [positive regulation of signal transduction]
GO:0035591 [signaling adaptor activity]
GO:0051016 [barbed-end actin filament capping]
GO:0051017 [actin filament bundle assembly]
Show all
 128 aa
14.5 kDa 		No 0
EPS8-009
ENSP00000438668
ENST00000536793
F5H2B8 [Direct mapping]
Epidermal growth factor receptor kinase substrate 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0009967 [positive regulation of signal transduction]
GO:0035591 [signaling adaptor activity]
GO:0051016 [barbed-end actin filament capping]
GO:0051017 [actin filament bundle assembly]
Show all
 68 aa
7.6 kDa 		No 0
EPS8-010
ENSP00000445815
ENST00000544064
F5H1B5 [Direct mapping]
Epidermal growth factor receptor kinase substrate 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0009967 [positive regulation of signal transduction]
GO:0035591 [signaling adaptor activity]
GO:0051016 [barbed-end actin filament capping]
GO:0051017 [actin filament bundle assembly]
Show all
 67 aa
7.5 kDa 		No 0
EPS8-017
ENSP00000440591
ENST00000535752
F5GYM8 [Direct mapping]
Epidermal growth factor receptor kinase substrate 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0009967 [positive regulation of signal transduction]
GO:0035591 [signaling adaptor activity]
GO:0051016 [barbed-end actin filament capping]
GO:0051017 [actin filament bundle assembly]
Show all
 121 aa
13.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.