Cell atlas - NCAPD3 - The Human Protein Atlas

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NCAPD3

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	NCAPD3
Gene description	Non-SMC condensin II complex, subunit D3
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA040286
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA040286	HEK 293	Nucleoplasm
	HPA040286	PC-3	Nucleoplasm
	HPA040286	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	NCAPD3 (HGNC Symbol)
Synonyms	CAP-D3, FLJ42888, hCAP-D3, hcp-6, hHCP-6, KIAA0056
Description	Non-SMC condensin II complex, subunit D3 (HGNC Symbol)
Entrez gene summary	Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Both condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 (MIM 605576) and SMC4 (MIM 605575), but they contain different sets of non-SMC subunits. NCAPD3 is 1 of 3 non-SMC subunits that define condensin II (Ono et al., 2003 [PubMed 14532007]).[supplied by OMIM, Mar 2008]
Chromosome	11
Cytoband	q25
Chromosome location (bp)	134150119 - 134225454
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151503 (version 83.38)
Entrez gene	23310
UniProt	P42695 (UniProt - Evidence at protein level)
neXtProt	NX_P42695
Antibodypedia	NCAPD3 antibodies

PROTEIN BROWSER

NCAPD3-001	NCAPD3-005	NCAPD3-006	NCAPD3-007	NCAPD3-008	NCAPD3-012	NCAPD3-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NCAPD3-001 ENSP00000433681 ENST00000534548	P42695 [Direct mapping] Condensin-2 complex subunit D3 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000779 [condensed chromosome, centromeric region] GO:0000793 [condensed chromosome] GO:0000799 [nuclear condensin complex] GO:0003682 [chromatin binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0007076 [mitotic chromosome condensation] GO:0010032 [meiotic chromosome condensation] GO:0016020 [membrane] GO:0031618 [nuclear pericentric heterochromatin] GO:0035064 [methylated histone binding] GO:0042585 [germinal vesicle] GO:0051301 [cell division] GO:0051304 [chromosome separation] Show all	1498 aa 168.9 kDa	No	0
NCAPD3-005 ENSP00000431436 ENST00000534227	E9PL84 [Direct mapping] Condensin-2 complex subunit D3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		35 aa 4 kDa	No	0
NCAPD3-006 ENSP00000435586 ENST00000526422	E9PJM8 [Direct mapping] Condensin-2 complex subunit D3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		37 aa 4 kDa	No	0
NCAPD3-007 ENSP00000435655 ENST00000532445	E9PJ63 [Direct mapping] Condensin-2 complex subunit D3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		33 aa 3.6 kDa	No	0
NCAPD3-008 ENSP00000436037 ENST00000525485	E9PR72 [Direct mapping] Condensin-2 complex subunit D3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007076 [mitotic chromosome condensation] Show all	74 aa 8.2 kDa	No	0
NCAPD3-012 ENSP00000435173 ENST00000530396	E9PLE0 [Direct mapping] Condensin-2 complex subunit D3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0007076 [mitotic chromosome condensation] Show all	264 aa 31.2 kDa	No	0
NCAPD3-013 ENSP00000432532 ENST00000527944	E9PQA3 [Direct mapping] Condensin-2 complex subunit D3 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007076 [mitotic chromosome condensation] Show all	195 aa 22.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.