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DRD3

GENERAL INFORMATION

Gene name

 DRD3

Gene description

 Dopamine receptor D3

Protein class

 Disease related genes
FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 DRD3

Synonyms

Description

 Dopamine receptor D3 (HGNC Symbol)

Entrez gene summary

 This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q13.31

Chromosome location (bp)

 114128652 - 114199407

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000151577 (version 83.38)

Entrez gene

 1814

UniProt

 P35462 (UniProt - Evidence at protein level)

neXtProt

 NX_P35462

Antibodypedia

 DRD3 antibodies

PROTEIN BROWSER
DRD3-001
DRD3-002
DRD3-201
DRD3-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DRD3-001
ENSP00000419402
ENST00000460779
P35462 [Direct mapping]
D(3) dopamine receptor
X5D2G4 [Target identity:100%; Query identity:100%]
Dopamine receptor D3 isoform A
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001591 [dopamine neurotransmitter receptor activity, coupled via Gi/Go]
GO:0002031 [G-protein coupled receptor internalization]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007195 [adenylate cyclase-inhibiting dopamine receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007606 [sensory perception of chemical stimulus]
GO:0007611 [learning or memory]
GO:0007612 [learning]
GO:0007626 [locomotory behavior]
GO:0008144 [drug binding]
GO:0008227 [G-protein coupled amine receptor activity]
GO:0008542 [visual learning]
GO:0014059 [regulation of dopamine secretion]
GO:0016021 [integral component of membrane]
GO:0030814 [regulation of cAMP metabolic process]
GO:0032467 [positive regulation of cytokinesis]
GO:0032922 [circadian regulation of gene expression]
GO:0034776 [response to histamine]
GO:0035176 [social behavior]
GO:0042220 [response to cocaine]
GO:0042417 [dopamine metabolic process]
GO:0042493 [response to drug]
GO:0043278 [response to morphine]
GO:0045776 [negative regulation of blood pressure]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0046717 [acid secretion]
GO:0048148 [behavioral response to cocaine]
GO:0048715 [negative regulation of oligodendrocyte differentiation]
GO:0050482 [arachidonic acid secretion]
GO:0050709 [negative regulation of protein secretion]
GO:0050883 [musculoskeletal movement, spinal reflex action]
GO:0051584 [regulation of dopamine uptake involved in synaptic transmission]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0060134 [prepulse inhibition]
GO:0060161 [positive regulation of dopamine receptor signaling pathway]
Show all
 400 aa
44.2 kDa 		No 7
DRD3-002
ENSP00000420662
ENST00000467632
P35462 [Direct mapping]
D(3) dopamine receptor
X5D2G4 [Target identity:100%; Query identity:100%]
Dopamine receptor D3 isoform A
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001591 [dopamine neurotransmitter receptor activity, coupled via Gi/Go]
GO:0002031 [G-protein coupled receptor internalization]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007195 [adenylate cyclase-inhibiting dopamine receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007606 [sensory perception of chemical stimulus]
GO:0007611 [learning or memory]
GO:0007612 [learning]
GO:0007626 [locomotory behavior]
GO:0008144 [drug binding]
GO:0008227 [G-protein coupled amine receptor activity]
GO:0008542 [visual learning]
GO:0014059 [regulation of dopamine secretion]
GO:0016021 [integral component of membrane]
GO:0030814 [regulation of cAMP metabolic process]
GO:0032467 [positive regulation of cytokinesis]
GO:0032922 [circadian regulation of gene expression]
GO:0034776 [response to histamine]
GO:0035176 [social behavior]
GO:0042220 [response to cocaine]
GO:0042417 [dopamine metabolic process]
GO:0042493 [response to drug]
GO:0043278 [response to morphine]
GO:0045776 [negative regulation of blood pressure]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0046717 [acid secretion]
GO:0048148 [behavioral response to cocaine]
GO:0048715 [negative regulation of oligodendrocyte differentiation]
GO:0050482 [arachidonic acid secretion]
GO:0050709 [negative regulation of protein secretion]
GO:0050883 [musculoskeletal movement, spinal reflex action]
GO:0051584 [regulation of dopamine uptake involved in synaptic transmission]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0060134 [prepulse inhibition]
GO:0060161 [positive regulation of dopamine receptor signaling pathway]
Show all
 400 aa
44.2 kDa 		No 7
DRD3-201
ENSP00000295881
ENST00000295881
E9PCM4 [Direct mapping]
D(3) dopamine receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004952 [dopamine neurotransmitter receptor activity]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007195 [adenylate cyclase-inhibiting dopamine receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007606 [sensory perception of chemical stimulus]
GO:0008227 [G-protein coupled amine receptor activity]
GO:0016021 [integral component of membrane]
Show all
 367 aa
40.7 kDa 		No 7
DRD3-202
ENSP00000373169
ENST00000383673
P35462 [Direct mapping]
D(3) dopamine receptor
X5D2G4 [Target identity:100%; Query identity:100%]
Dopamine receptor D3 isoform A
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001591 [dopamine neurotransmitter receptor activity, coupled via Gi/Go]
GO:0001963 [synaptic transmission, dopaminergic]
GO:0001975 [response to amphetamine]
GO:0002016 [regulation of blood volume by renin-angiotensin]
GO:0002031 [G-protein coupled receptor internalization]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007195 [adenylate cyclase-inhibiting dopamine receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007606 [sensory perception of chemical stimulus]
GO:0007611 [learning or memory]
GO:0007612 [learning]
GO:0007626 [locomotory behavior]
GO:0008144 [drug binding]
GO:0008227 [G-protein coupled amine receptor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008542 [visual learning]
GO:0014059 [regulation of dopamine secretion]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019216 [regulation of lipid metabolic process]
GO:0019904 [protein domain specific binding]
GO:0030139 [endocytic vesicle]
GO:0030814 [regulation of cAMP metabolic process]
GO:0031748 [D1 dopamine receptor binding]
GO:0032416 [negative regulation of sodium:proton antiporter activity]
GO:0032467 [positive regulation of cytokinesis]
GO:0032922 [circadian regulation of gene expression]
GO:0034776 [response to histamine]
GO:0035176 [social behavior]
GO:0035240 [dopamine binding]
GO:0035483 [gastric emptying]
GO:0035815 [positive regulation of renal sodium excretion]
GO:0040012 [regulation of locomotion]
GO:0040014 [regulation of multicellular organism growth]
GO:0042220 [response to cocaine]
GO:0042417 [dopamine metabolic process]
GO:0042493 [response to drug]
GO:0042995 [cell projection]
GO:0043278 [response to morphine]
GO:0045177 [apical part of cell]
GO:0045187 [regulation of circadian sleep/wake cycle, sleep]
GO:0045471 [response to ethanol]
GO:0045776 [negative regulation of blood pressure]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046717 [acid secretion]
GO:0048148 [behavioral response to cocaine]
GO:0048715 [negative regulation of oligodendrocyte differentiation]
GO:0050482 [arachidonic acid secretion]
GO:0050709 [negative regulation of protein secretion]
GO:0050883 [musculoskeletal movement, spinal reflex action]
GO:0051584 [regulation of dopamine uptake involved in synaptic transmission]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0060134 [prepulse inhibition]
GO:0060160 [negative regulation of dopamine receptor signaling pathway]
GO:0060161 [positive regulation of dopamine receptor signaling pathway]
GO:0090325 [regulation of locomotion involved in locomotory behavior]
Show all
 400 aa
44.2 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.