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ADAM8

GENERAL INFORMATION

Gene name

 ADAM8

Gene description

 ADAM metallopeptidase domain 8

Protein class

 CD markers
Enzymes
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (A-431, BEWO, CAPAN-2, HaCaT, HDLM-2)
HPA (normal tissue):Tissue enhanced (bone marrow, spleen)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues with additional expression in immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA064637
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY
HPA064637

GENE INFORMATION

Gene name

 ADAM8 (HGNC Symbol)

Synonyms

 CD156, CD156a, MS2

Description

 ADAM metallopeptidase domain 8 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]

Chromosome

 10

Cytoband

 q26.3

Chromosome location (bp)

 133262403 - 133276868

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000151651 (version 83.38)

Entrez gene

 101

UniProt

 P78325 (UniProt - Evidence at protein level)

neXtProt

 NX_P78325

Antibodypedia

 ADAM8 antibodies

PROTEIN BROWSER
ADAM8-001
ADAM8-004
ADAM8-005
ADAM8-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADAM8-001
ENSP00000453302
ENST00000445355
P78325 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 8
Show all
Enzymes
   Peptidases
   Metallopeptidases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0001525 [angiogenesis]
GO:0002102 [podosome]
GO:0002523 [leukocyte migration involved in inflammatory response]
GO:0002675 [positive regulation of acute inflammatory response]
GO:0002693 [positive regulation of cellular extravasation]
GO:0004222 [metalloendopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006508 [proteolysis]
GO:0006954 [inflammatory response]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0010954 [positive regulation of protein processing]
GO:0016337 [single organismal cell-cell adhesion]
GO:0022407 [regulation of cell-cell adhesion]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0032010 [phagolysosome]
GO:0032127 [dense core granule membrane]
GO:0033089 [positive regulation of T cell differentiation in thymus]
GO:0035419 [activation of MAPK activity involved in innate immune response]
GO:0042581 [specific granule]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043621 [protein self-association]
GO:0045780 [positive regulation of bone resorption]
GO:0045785 [positive regulation of cell adhesion]
GO:0048247 [lymphocyte chemotaxis]
GO:0050714 [positive regulation of protein secretion]
GO:0050729 [positive regulation of inflammatory response]
GO:0050839 [cell adhesion molecule binding]
GO:0051044 [positive regulation of membrane protein ectodomain proteolysis]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070245 [positive regulation of thymocyte apoptotic process]
GO:0070820 [tertiary granule]
GO:0071065 [alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex]
GO:0071133 [alpha9-beta1 integrin-ADAM8 complex]
GO:0071456 [cellular response to hypoxia]
GO:2000309 [positive regulation of tumor necrosis factor (ligand) superfamily member 11 production]
GO:2000391 [positive regulation of neutrophil extravasation]
GO:2000406 [positive regulation of T cell migration]
GO:2000415 [positive regulation of fibronectin-dependent thymocyte migration]
GO:2000418 [positive regulation of eosinophil migration]
Show all
 824 aa
88.8 kDa 		Yes 1
ADAM8-004
ENSP00000453735
ENST00000486609
H0YMT6 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 8
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
Show all
 245 aa
26.9 kDa 		Yes 0
ADAM8-005
ENSP00000453043
ENST00000485491
P78325 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 8
Show all
Enzymes
   Peptidases
   Metallopeptidases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0001525 [angiogenesis]
GO:0002102 [podosome]
GO:0002523 [leukocyte migration involved in inflammatory response]
GO:0002675 [positive regulation of acute inflammatory response]
GO:0004222 [metalloendopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006508 [proteolysis]
GO:0006954 [inflammatory response]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0010954 [positive regulation of protein processing]
GO:0022407 [regulation of cell-cell adhesion]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0032010 [phagolysosome]
GO:0032127 [dense core granule membrane]
GO:0033089 [positive regulation of T cell differentiation in thymus]
GO:0035419 [activation of MAPK activity involved in innate immune response]
GO:0042581 [specific granule]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043621 [protein self-association]
GO:0045780 [positive regulation of bone resorption]
GO:0045785 [positive regulation of cell adhesion]
GO:0048247 [lymphocyte chemotaxis]
GO:0050714 [positive regulation of protein secretion]
GO:0050839 [cell adhesion molecule binding]
GO:0051044 [positive regulation of membrane protein ectodomain proteolysis]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070245 [positive regulation of thymocyte apoptotic process]
GO:0070820 [tertiary granule]
GO:0071065 [alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex]
GO:0071133 [alpha9-beta1 integrin-ADAM8 complex]
GO:0071456 [cellular response to hypoxia]
GO:2000309 [positive regulation of tumor necrosis factor (ligand) superfamily member 11 production]
GO:2000391 [positive regulation of neutrophil extravasation]
GO:2000415 [positive regulation of fibronectin-dependent thymocyte migration]
GO:2000418 [positive regulation of eosinophil migration]
Show all
 733 aa
78.8 kDa 		Yes 1
ADAM8-009
ENSP00000453855
ENST00000415217
P78325 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 8
Show all
Enzymes
   Peptidases
   Metallopeptidases
CD markers
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0001525 [angiogenesis]
GO:0002102 [podosome]
GO:0002523 [leukocyte migration involved in inflammatory response]
GO:0002675 [positive regulation of acute inflammatory response]
GO:0004222 [metalloendopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006508 [proteolysis]
GO:0006954 [inflammatory response]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0010954 [positive regulation of protein processing]
GO:0022407 [regulation of cell-cell adhesion]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0032010 [phagolysosome]
GO:0032127 [dense core granule membrane]
GO:0033089 [positive regulation of T cell differentiation in thymus]
GO:0035419 [activation of MAPK activity involved in innate immune response]
GO:0042581 [specific granule]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043621 [protein self-association]
GO:0045780 [positive regulation of bone resorption]
GO:0045785 [positive regulation of cell adhesion]
GO:0048247 [lymphocyte chemotaxis]
GO:0050714 [positive regulation of protein secretion]
GO:0050839 [cell adhesion molecule binding]
GO:0051044 [positive regulation of membrane protein ectodomain proteolysis]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070245 [positive regulation of thymocyte apoptotic process]
GO:0070820 [tertiary granule]
GO:0071065 [alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex]
GO:0071133 [alpha9-beta1 integrin-ADAM8 complex]
GO:0071456 [cellular response to hypoxia]
GO:2000309 [positive regulation of tumor necrosis factor (ligand) superfamily member 11 production]
GO:2000391 [positive regulation of neutrophil extravasation]
GO:2000415 [positive regulation of fibronectin-dependent thymocyte migration]
GO:2000418 [positive regulation of eosinophil migration]
Show all
 742 aa
80.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.