Cancers exhibited weak to moderate cytoplasmic positivity. Carcinoids, gliomas, lymphomas, skin, head and neck cancers were mostly negative.
ADAM8 (HGNC Symbol)
CD156, CD156a, MS2
ADAM metallopeptidase domain 8 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]