Expression of ADAM8 in cancer - Summary

GENERAL INFORMATION
Gene nameⁱ Gene name according to HGNC.	ADAM8
Gene descriptionⁱ Gene description according to HGNC.	ADAM metallopeptidase domain 8
Protein classⁱ Protein class the gene product belongs to according to selected gene lists. List of protein classes.	CD markers Enzymes Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localizationⁱ Protein localization predicted from several bioinformatic algorithms. Read more	Membrane,Secreted
Number of transcriptsⁱ Number of protein-coding transcribed from this gene as defined by Ensembl.	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA categoryⁱ

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (A-431, BEWO, CAPAN-2, HaCaT, HDLM-2)
HPA (normal tissue):	Tissue enhanced (bone marrow, spleen)

Protein evidenceⁱ

Evidence at protein level

Protein expression
normal tissueⁱ

Cytoplasmic expression in several tissues with additional expression in immune cells.

ANTIBODY IHC RELIABILITY
Data reliability descriptionⁱ Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.	Antibody staining mainly not consistent with RNA expression data.
Reliability scoreⁱ Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data. Read more	Approved based on 1 antibody. HPA064637
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PROGNOSTIC SUMMARYⁱ Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEWⁱ

TCGA datasetⁱ
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name.

Read more

RNA cancer category: Expressed in all

PROTEIN EXPRESSIONⁱ

STAINING SUMMARYⁱ

HPA064637

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	ADAM8 (HGNC Symbol)
Synonyms	CD156, CD156a, MS2
Description	ADAM metallopeptidase domain 8 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]
Chromosome	10
Cytoband	q26.3
Chromosome location (bp)	133262403 - 133276868
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151651 (version 83.38)
Entrez gene	101
UniProt	P78325 (UniProt - Evidence at protein level)
neXtProt	NX_P78325
Antibodypedia	ADAM8 antibodies

PROTEIN BROWSERⁱ

ADAM8-001	ADAM8-004	ADAM8-005	ADAM8-009

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAM8-001 ENSP00000453302 ENST00000445355	P78325 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 8 Show all	Enzymes Peptidases Metallopeptidases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000902 [cell morphogenesis] GO:0001525 [angiogenesis] GO:0002102 [podosome] GO:0002523 [leukocyte migration involved in inflammatory response] GO:0002675 [positive regulation of acute inflammatory response] GO:0002693 [positive regulation of cellular extravasation] GO:0004222 [metalloendopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0006954 [inflammatory response] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0009986 [cell surface] GO:0010954 [positive regulation of protein processing] GO:0016337 [single organismal cell-cell adhesion] GO:0022407 [regulation of cell-cell adhesion] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0032010 [phagolysosome] GO:0032127 [dense core granule membrane] GO:0033089 [positive regulation of T cell differentiation in thymus] GO:0035419 [activation of MAPK activity involved in innate immune response] GO:0042581 [specific granule] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043621 [protein self-association] GO:0045780 [positive regulation of bone resorption] GO:0045785 [positive regulation of cell adhesion] GO:0048247 [lymphocyte chemotaxis] GO:0050714 [positive regulation of protein secretion] GO:0050729 [positive regulation of inflammatory response] GO:0050839 [cell adhesion molecule binding] GO:0051044 [positive regulation of membrane protein ectodomain proteolysis] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051897 [positive regulation of protein kinase B signaling] GO:0070245 [positive regulation of thymocyte apoptotic process] GO:0070820 [tertiary granule] GO:0071065 [alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex] GO:0071133 [alpha9-beta1 integrin-ADAM8 complex] GO:0071456 [cellular response to hypoxia] GO:2000309 [positive regulation of tumor necrosis factor (ligand) superfamily member 11 production] GO:2000391 [positive regulation of neutrophil extravasation] GO:2000406 [positive regulation of T cell migration] GO:2000415 [positive regulation of fibronectin-dependent thymocyte migration] GO:2000418 [positive regulation of eosinophil migration] Show all	824 aa 88.8 kDa	Yes	1
ADAM8-004 ENSP00000453735 ENST00000486609	H0YMT6 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 8 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	245 aa 26.9 kDa	Yes	0
ADAM8-005 ENSP00000453043 ENST00000485491	P78325 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 8 Show all	Enzymes Peptidases Metallopeptidases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000902 [cell morphogenesis] GO:0001525 [angiogenesis] GO:0002102 [podosome] GO:0002523 [leukocyte migration involved in inflammatory response] GO:0002675 [positive regulation of acute inflammatory response] GO:0004222 [metalloendopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0006954 [inflammatory response] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0009986 [cell surface] GO:0010954 [positive regulation of protein processing] GO:0022407 [regulation of cell-cell adhesion] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0032010 [phagolysosome] GO:0032127 [dense core granule membrane] GO:0033089 [positive regulation of T cell differentiation in thymus] GO:0035419 [activation of MAPK activity involved in innate immune response] GO:0042581 [specific granule] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043621 [protein self-association] GO:0045780 [positive regulation of bone resorption] GO:0045785 [positive regulation of cell adhesion] GO:0048247 [lymphocyte chemotaxis] GO:0050714 [positive regulation of protein secretion] GO:0050839 [cell adhesion molecule binding] GO:0051044 [positive regulation of membrane protein ectodomain proteolysis] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051897 [positive regulation of protein kinase B signaling] GO:0070245 [positive regulation of thymocyte apoptotic process] GO:0070820 [tertiary granule] GO:0071065 [alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex] GO:0071133 [alpha9-beta1 integrin-ADAM8 complex] GO:0071456 [cellular response to hypoxia] GO:2000309 [positive regulation of tumor necrosis factor (ligand) superfamily member 11 production] GO:2000391 [positive regulation of neutrophil extravasation] GO:2000415 [positive regulation of fibronectin-dependent thymocyte migration] GO:2000418 [positive regulation of eosinophil migration] Show all	733 aa 78.8 kDa	Yes	1
ADAM8-009 ENSP00000453855 ENST00000415217	P78325 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 8 Show all	Enzymes Peptidases Metallopeptidases CD markers MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000902 [cell morphogenesis] GO:0001525 [angiogenesis] GO:0002102 [podosome] GO:0002523 [leukocyte migration involved in inflammatory response] GO:0002675 [positive regulation of acute inflammatory response] GO:0004222 [metalloendopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0006954 [inflammatory response] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0009986 [cell surface] GO:0010954 [positive regulation of protein processing] GO:0022407 [regulation of cell-cell adhesion] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0032010 [phagolysosome] GO:0032127 [dense core granule membrane] GO:0033089 [positive regulation of T cell differentiation in thymus] GO:0035419 [activation of MAPK activity involved in innate immune response] GO:0042581 [specific granule] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043621 [protein self-association] GO:0045780 [positive regulation of bone resorption] GO:0045785 [positive regulation of cell adhesion] GO:0048247 [lymphocyte chemotaxis] GO:0050714 [positive regulation of protein secretion] GO:0050839 [cell adhesion molecule binding] GO:0051044 [positive regulation of membrane protein ectodomain proteolysis] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051897 [positive regulation of protein kinase B signaling] GO:0070245 [positive regulation of thymocyte apoptotic process] GO:0070820 [tertiary granule] GO:0071065 [alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex] GO:0071133 [alpha9-beta1 integrin-ADAM8 complex] GO:0071456 [cellular response to hypoxia] GO:2000309 [positive regulation of tumor necrosis factor (ligand) superfamily member 11 production] GO:2000391 [positive regulation of neutrophil extravasation] GO:2000415 [positive regulation of fibronectin-dependent thymocyte migration] GO:2000418 [positive regulation of eosinophil migration] Show all	742 aa 80.3 kDa	Yes	0