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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ADAM8
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ADAM8

Gene description

ADAM metallopeptidase domain 8

Protein class

CD markers
Enzymes
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (A-431, BEWO, CAPAN-2, HaCaT, HDLM-2)
HPA (normal tissue):Tissue enhanced (bone marrow, spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues with additional expression in immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA064637
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY

HPA064637

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancers exhibited weak to moderate cytoplasmic positivity. Carcinoids, gliomas, lymphomas, skin, head and neck cancers were mostly negative.

GENE INFORMATION

Gene name

ADAM8 (HGNC Symbol)

Synonyms

CD156, CD156a, MS2

Description

ADAM metallopeptidase domain 8 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]

Chromosome

10

Cytoband

q26.3

Chromosome location (bp)

133262403 - 133276868

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000151651 (version 83.38)

Entrez gene

101

UniProt

P78325 (UniProt - Evidence at protein level)

neXtProt

NX_P78325

Antibodypedia

ADAM8 antibodies

PROTEIN BROWSER

ADAM8-001
ADAM8-004
ADAM8-005
ADAM8-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAM8-001
ENSP00000453302
ENST00000445355
P78325 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 8
Show all
Enzymes
   Peptidases
   Metallopeptidases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0001525 [angiogenesis]
GO:0002102 [podosome]
GO:0002523 [leukocyte migration involved in inflammatory response]
GO:0002675 [positive regulation of acute inflammatory response]
GO:0002693 [positive regulation of cellular extravasation]
GO:0004222 [metalloendopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006508 [proteolysis]
GO:0006954 [inflammatory response]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0010954 [positive regulation of protein processing]
GO:0016337 [single organismal cell-cell adhesion]
GO:0022407 [regulation of cell-cell adhesion]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0032010 [phagolysosome]
GO:0032127 [dense core granule membrane]
GO:0033089 [positive regulation of T cell differentiation in thymus]
GO:0035419 [activation of MAPK activity involved in innate immune response]
GO:0042581 [specific granule]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043621 [protein self-association]
GO:0045780 [positive regulation of bone resorption]
GO:0045785 [positive regulation of cell adhesion]
GO:0048247 [lymphocyte chemotaxis]
GO:0050714 [positive regulation of protein secretion]
GO:0050729 [positive regulation of inflammatory response]
GO:0050839 [cell adhesion molecule binding]
GO:0051044 [positive regulation of membrane protein ectodomain proteolysis]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070245 [positive regulation of thymocyte apoptotic process]
GO:0070820 [tertiary granule]
GO:0071065 [alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex]
GO:0071133 [alpha9-beta1 integrin-ADAM8 complex]
GO:0071456 [cellular response to hypoxia]
GO:2000309 [positive regulation of tumor necrosis factor (ligand) superfamily member 11 production]
GO:2000391 [positive regulation of neutrophil extravasation]
GO:2000406 [positive regulation of T cell migration]
GO:2000415 [positive regulation of fibronectin-dependent thymocyte migration]
GO:2000418 [positive regulation of eosinophil migration]
Show all
824 aa
88.8 kDa
Yes 1
ADAM8-004
ENSP00000453735
ENST00000486609
H0YMT6 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 8
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
Show all
245 aa
26.9 kDa
Yes 0
ADAM8-005
ENSP00000453043
ENST00000485491
P78325 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 8
Show all
Enzymes
   Peptidases
   Metallopeptidases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0001525 [angiogenesis]
GO:0002102 [podosome]
GO:0002523 [leukocyte migration involved in inflammatory response]
GO:0002675 [positive regulation of acute inflammatory response]
GO:0004222 [metalloendopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006508 [proteolysis]
GO:0006954 [inflammatory response]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0010954 [positive regulation of protein processing]
GO:0022407 [regulation of cell-cell adhesion]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0032010 [phagolysosome]
GO:0032127 [dense core granule membrane]
GO:0033089 [positive regulation of T cell differentiation in thymus]
GO:0035419 [activation of MAPK activity involved in innate immune response]
GO:0042581 [specific granule]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043621 [protein self-association]
GO:0045780 [positive regulation of bone resorption]
GO:0045785 [positive regulation of cell adhesion]
GO:0048247 [lymphocyte chemotaxis]
GO:0050714 [positive regulation of protein secretion]
GO:0050839 [cell adhesion molecule binding]
GO:0051044 [positive regulation of membrane protein ectodomain proteolysis]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070245 [positive regulation of thymocyte apoptotic process]
GO:0070820 [tertiary granule]
GO:0071065 [alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex]
GO:0071133 [alpha9-beta1 integrin-ADAM8 complex]
GO:0071456 [cellular response to hypoxia]
GO:2000309 [positive regulation of tumor necrosis factor (ligand) superfamily member 11 production]
GO:2000391 [positive regulation of neutrophil extravasation]
GO:2000415 [positive regulation of fibronectin-dependent thymocyte migration]
GO:2000418 [positive regulation of eosinophil migration]
Show all
733 aa
78.8 kDa
Yes 1
ADAM8-009
ENSP00000453855
ENST00000415217
P78325 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 8
Show all
Enzymes
   Peptidases
   Metallopeptidases
CD markers
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0001525 [angiogenesis]
GO:0002102 [podosome]
GO:0002523 [leukocyte migration involved in inflammatory response]
GO:0002675 [positive regulation of acute inflammatory response]
GO:0004222 [metalloendopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006508 [proteolysis]
GO:0006954 [inflammatory response]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0010954 [positive regulation of protein processing]
GO:0022407 [regulation of cell-cell adhesion]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0032010 [phagolysosome]
GO:0032127 [dense core granule membrane]
GO:0033089 [positive regulation of T cell differentiation in thymus]
GO:0035419 [activation of MAPK activity involved in innate immune response]
GO:0042581 [specific granule]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043621 [protein self-association]
GO:0045780 [positive regulation of bone resorption]
GO:0045785 [positive regulation of cell adhesion]
GO:0048247 [lymphocyte chemotaxis]
GO:0050714 [positive regulation of protein secretion]
GO:0050839 [cell adhesion molecule binding]
GO:0051044 [positive regulation of membrane protein ectodomain proteolysis]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070245 [positive regulation of thymocyte apoptotic process]
GO:0070820 [tertiary granule]
GO:0071065 [alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex]
GO:0071133 [alpha9-beta1 integrin-ADAM8 complex]
GO:0071456 [cellular response to hypoxia]
GO:2000309 [positive regulation of tumor necrosis factor (ligand) superfamily member 11 production]
GO:2000391 [positive regulation of neutrophil extravasation]
GO:2000415 [positive regulation of fibronectin-dependent thymocyte migration]
GO:2000418 [positive regulation of eosinophil migration]
Show all
742 aa
80.3 kDa
Yes 0

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  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.