Expression of INPP1 in cancer - Summary - The Human Protein Atlas

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INPP1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	INPP1
Gene description	Inositol polyphosphate-1-phosphatase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression with a few cases of low nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA036698 , HPA036699
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (favourable) and urothelial cancer (favourable).
Thyroid cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036698	HPA036699

GENE INFORMATION
Gene name	INPP1
Synonyms
Description	Inositol polyphosphate-1-phosphatase (HGNC Symbol)
Entrez gene summary	This gene encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q32.2
Chromosome location (bp)	190343470 - 190371665
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151689 (version 83.38)
Entrez gene	3628
UniProt	P49441 (UniProt - Evidence at protein level)
neXtProt	NX_P49441
Antibodypedia	INPP1 antibodies

PROTEIN BROWSER

INPP1-001	INPP1-002	INPP1-003	INPP1-005	INPP1-006	INPP1-007	INPP1-009	INPP1-010	INPP1-011	INPP1-014	INPP1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
INPP1-001 ENSP00000325423 ENST00000322522	P49441 [Direct mapping] Inositol polyphosphate 1-phosphatase Q6IBG4 [Target identity:100%; Query identity:100%] INPP1 protein; Inositol polyphosphate-1-phosphatase; Inositol polyphosphate-1-phosphatase, isoform CRA_a; Putative uncharacterized protein INPP1 Show all	Enzymes ENZYME proteins Hydrolases SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004441 [inositol-1,4-bisphosphate 1-phosphatase activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006796 [phosphate-containing compound metabolic process] GO:0007165 [signal transduction] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] GO:0046854 [phosphatidylinositol phosphorylation] GO:0046855 [inositol phosphate dephosphorylation] GO:0052829 [inositol-1,3,4-trisphosphate 1-phosphatase activity] Show all	399 aa 44 kDa	No	0
INPP1-002 ENSP00000404732 ENST00000444194	E7ET59 [Direct mapping] Inositol polyphosphate 1-phosphatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046854 [phosphatidylinositol phosphorylation] Show all	190 aa 21.3 kDa	No	0
INPP1-003 ENSP00000392814 ENST00000458647	C9J173 [Direct mapping] Inositol polyphosphate 1-phosphatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046854 [phosphatidylinositol phosphorylation] Show all	143 aa 16.1 kDa	No	0
INPP1-005 ENSP00000415014 ENST00000430311		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		9 aa 1.1 kDa	No	0
INPP1-006 ENSP00000391415 ENST00000413239	C9J2Z6 [Direct mapping] Inositol polyphosphate 1-phosphatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046854 [phosphatidylinositol phosphorylation] Show all	88 aa 10.2 kDa	No	0
INPP1-007 ENSP00000409786 ENST00000431594	E7ENF2 [Direct mapping] Inositol polyphosphate 1-phosphatase Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046854 [phosphatidylinositol phosphorylation] Show all	213 aa 23.8 kDa	No	0
INPP1-009 ENSP00000395424 ENST00000423767	E7EUX4 [Direct mapping] Inositol polyphosphate 1-phosphatase Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046854 [phosphatidylinositol phosphorylation] Show all	212 aa 23.6 kDa	No	0
INPP1-010 ENSP00000410662 ENST00000451089	C9J2N5 [Direct mapping] Inositol polyphosphate 1-phosphatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		30 aa 3.4 kDa	No	0
INPP1-011 ENSP00000412119 ENST00000458193	C9J128 [Direct mapping] Inositol polyphosphate 1-phosphatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046854 [phosphatidylinositol phosphorylation] Show all	68 aa 7.8 kDa	No	0
INPP1-014 ENSP00000387079 ENST00000409027	B8ZZF6 [Direct mapping] Inositol polyphosphate 1-phosphatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046854 [phosphatidylinositol phosphorylation] Show all	155 aa 17.5 kDa	No	0
INPP1-201 ENSP00000376142 ENST00000392329	P49441 [Direct mapping] Inositol polyphosphate 1-phosphatase Q6IBG4 [Target identity:100%; Query identity:100%] INPP1 protein; Inositol polyphosphate-1-phosphatase; Inositol polyphosphate-1-phosphatase, isoform CRA_a; Putative uncharacterized protein INPP1 Show all	Enzymes ENZYME proteins Hydrolases SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004441 [inositol-1,4-bisphosphate 1-phosphatase activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006796 [phosphate-containing compound metabolic process] GO:0007165 [signal transduction] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] GO:0046854 [phosphatidylinositol phosphorylation] GO:0046855 [inositol phosphate dephosphorylation] GO:0052829 [inositol-1,3,4-trisphosphate 1-phosphatase activity] Show all	399 aa 44 kDa	No	0

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