Expression of MFSD6 in cancer - Summary - The Human Protein Atlas

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MFSD6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MFSD6
Gene description	Major facilitator superfamily domain containing 6
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic and membranous expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA022274
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA022274

GENE INFORMATION
Gene name	MFSD6 (HGNC Symbol)
Synonyms	FLJ20160
Description	Major facilitator superfamily domain containing 6 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q32.2
Chromosome location (bp)	190408355 - 190509205
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151690 (version 83.38)
Entrez gene	54842
UniProt	Q6ZSS7 (UniProt - Evidence at protein level)
neXtProt	NX_Q6ZSS7
Antibodypedia	MFSD6 antibodies

PROTEIN BROWSER

MFSD6-001	MFSD6-002	MFSD6-003	MFSD6-004	MFSD6-006	MFSD6-008	MFSD6-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MFSD6-001 ENSP00000376141 ENST00000392328	Q6ZSS7 [Direct mapping] Major facilitator superfamily domain-containing protein 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	791 aa 88.1 kDa	No	>9
MFSD6-002 ENSP00000400131 ENST00000432036	C9J134 [Direct mapping] Major facilitator superfamily domain-containing protein 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	114 aa 13.1 kDa	No	1
MFSD6-003 ENSP00000398737 ENST00000417958	C9JAZ7 [Direct mapping] Major facilitator superfamily domain-containing protein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		42 aa 4.7 kDa	No	0
MFSD6-004 ENSP00000403762 ENST00000445546	C9JJH2 [Direct mapping] Major facilitator superfamily domain-containing protein 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	156 aa 17.8 kDa	No	3
MFSD6-006 ENSP00000397276 ENST00000434582	H7C0X2 [Direct mapping] Major facilitator superfamily domain-containing protein 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	271 aa 30 kDa	No	5
MFSD6-008 ENSP00000406837 ENST00000444317	C9IYL1 [Direct mapping] Major facilitator superfamily domain-containing protein 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	179 aa 19.6 kDa	Yes	2
MFSD6-201 ENSP00000281416 ENST00000281416	Q6ZSS7 [Direct mapping] Major facilitator superfamily domain-containing protein 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	791 aa 88.1 kDa	No	>9

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.