Expression of WWC2 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

WWC2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	WWC2
Gene description	WW and C2 domain containing 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (SiHa)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA044005
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (unfavourable) and renal cancer (favourable).
Cervical cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044005

GENE INFORMATION
Gene name	WWC2 (HGNC Symbol)
Synonyms	BOMB, FLJ22029
Description	WW and C2 domain containing 2 (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	q35.1
Chromosome location (bp)	183099293 - 183320777
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151718 (version 83.38)
Entrez gene	80014
UniProt	Q6AWC2 (UniProt - Evidence at protein level)
neXtProt	NX_Q6AWC2
Antibodypedia	WWC2 antibodies

PROTEIN BROWSER

WWC2-003	WWC2-004	WWC2-005	WWC2-006	WWC2-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WWC2-003 ENSP00000384222 ENST00000403733	Q6AWC2 [Direct mapping] Protein WWC2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0019900 [kinase binding] GO:0032947 [protein complex scaffold] GO:0035331 [negative regulation of hippo signaling] GO:0046621 [negative regulation of organ growth] Show all	1192 aa 133.9 kDa	No	0
WWC2-004 ENSP00000427569 ENST00000504005	Q6AWC2 [Direct mapping] Protein WWC2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0019900 [kinase binding] GO:0032947 [protein complex scaffold] GO:0035331 [negative regulation of hippo signaling] GO:0046621 [negative regulation of organ growth] Show all	874 aa 97.4 kDa	No	0
WWC2-005 ENSP00000425054 ENST00000513834	Q6AWC2 [Direct mapping] Protein WWC2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0019900 [kinase binding] GO:0032947 [protein complex scaffold] GO:0035331 [negative regulation of hippo signaling] GO:0046621 [negative regulation of organ growth] Show all	1143 aa 128.7 kDa	No	0
WWC2-006 ENSP00000398577 ENST00000448232	Q6AWC2 [Direct mapping] Protein WWC2 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0019900 [kinase binding] GO:0032947 [protein complex scaffold] GO:0035331 [negative regulation of hippo signaling] GO:0046621 [negative regulation of organ growth] Show all	1216 aa 136.8 kDa	No	0
WWC2-007 ENSP00000420835 ENST00000508747	Q6AWC2 [Direct mapping] Protein WWC2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005829 [cytosol] GO:0019900 [kinase binding] GO:0032947 [protein complex scaffold] GO:0035331 [negative regulation of hippo signaling] GO:0046621 [negative regulation of organ growth] Show all	320 aa 36.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.