Expression of CENPU in cancer - Summary

GENERAL INFORMATION
Gene name	CENPU
Gene description	Centromere protein U
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Tissue enhanced (bone marrow, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissues, most abundant in lymphoid tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA022048
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), pancreatic cancer (unfavourable) and lung cancer (unfavourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA022048

GENE INFORMATION
Gene name	CENPU (HGNC Symbol)
Synonyms	CENP-50, CENP-U, KLIP1, MLF1IP, PBIP1
Description	Centromere protein U (HGNC Symbol)
Entrez gene summary	The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). MLF1IP, or CENPU, is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008]
Chromosome	4
Cytoband	q35.1
Chromosome location (bp)	184694618 - 184734133
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151725 (version 83.38)
Entrez gene	79682
UniProt	Q71F23 (UniProt - Evidence at protein level)
neXtProt	NX_Q71F23
Antibodypedia	CENPU antibodies

PROTEIN BROWSER

CENPU-001	CENPU-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CENPU-001 ENSP00000281453 ENST00000281453	Q71F23 [Direct mapping] Centromere protein U Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000777 [condensed chromosome kinetochore] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0006334 [nucleosome assembly] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007264 [small GTPase mediated signal transduction] GO:0016032 [viral process] GO:0034080 [CENP-A containing nucleosome assembly] GO:0043009 [chordate embryonic development] Show all	418 aa 47.5 kDa	No	0
CENPU-004 ENSP00000423167 ENST00000514781	D6R9S4 [Direct mapping] Centromere protein U Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005815 [microtubule organizing center] Show all	177 aa 19.4 kDa	No	0