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ACSL1

GENERAL INFORMATION

Gene name

 ACSL1

Gene description

 Acyl-CoA synthetase long-chain family member 1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA011316 , HPA011964
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA011316
HPA011964

GENE INFORMATION

Gene name

 ACSL1 (HGNC Symbol)

Synonyms

 ACS1, FACL1, FACL2, LACS, LACS1, LACS2

Description

 Acyl-CoA synthetase long-chain family member 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Chromosome

 4

Cytoband

 q35.1

Chromosome location (bp)

 184755595 - 184826818

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000151726 (version 83.38)

Entrez gene

 2180

UniProt

 P33121 (UniProt - Evidence at protein level)

neXtProt

 NX_P33121

Antibodypedia

 ACSL1 antibodies

PROTEIN BROWSER
ACSL1-001
ACSL1-002
ACSL1-004
ACSL1-005
ACSL1-006
ACSL1-007
ACSL1-008
ACSL1-009
ACSL1-011
ACSL1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACSL1-001
ENSP00000281455
ENST00000281455
P33121 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 1
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001676 [long-chain fatty acid metabolic process]
GO:0003824 [catalytic activity]
GO:0004467 [long-chain fatty acid-CoA ligase activity]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005778 [peroxisomal membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0008152 [metabolic process]
GO:0008610 [lipid biosynthetic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0033559 [unsaturated fatty acid metabolic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0036109 [alpha-linolenic acid metabolic process]
GO:0043651 [linoleic acid metabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044539 [long-chain fatty acid import]
Show all
 698 aa
77.9 kDa 		No 2
ACSL1-002
ENSP00000425006
ENST00000504342
P33121 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 1
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001676 [long-chain fatty acid metabolic process]
GO:0003824 [catalytic activity]
GO:0004467 [long-chain fatty acid-CoA ligase activity]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005778 [peroxisomal membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0008152 [metabolic process]
GO:0008610 [lipid biosynthetic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0033559 [unsaturated fatty acid metabolic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0036109 [alpha-linolenic acid metabolic process]
GO:0043651 [linoleic acid metabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044539 [long-chain fatty acid import]
Show all
 698 aa
77.9 kDa 		No 2
ACSL1-004
ENSP00000424935
ENST00000504900
D6RER0 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
Show all
 388 aa
43.4 kDa 		No 2
ACSL1-005
ENSP00000407165
ENST00000454703
B7Z3Z9 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 1; cDNA FLJ53511, highly similar to Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3)
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
GO:0016874 [ligase activity]
Show all
 527 aa
58.6 kDa 		No 0
ACSL1-006
ENSP00000426244
ENST00000507295
E7EPM6 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
Show all
 664 aa
74.3 kDa 		No 2
ACSL1-007
ENSP00000426150
ENST00000513317
P33121 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 1
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001676 [long-chain fatty acid metabolic process]
GO:0003824 [catalytic activity]
GO:0004467 [long-chain fatty acid-CoA ligase activity]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005778 [peroxisomal membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0008152 [metabolic process]
GO:0008610 [lipid biosynthetic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0033559 [unsaturated fatty acid metabolic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0036109 [alpha-linolenic acid metabolic process]
GO:0043651 [linoleic acid metabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044539 [long-chain fatty acid import]
Show all
 698 aa
77.9 kDa 		No 2
ACSL1-008
ENSP00000425640
ENST00000505492
H0Y9Z9 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
Show all
 94 aa
10.1 kDa 		No 0
ACSL1-009
ENSP00000425098
ENST00000503407
H0Y9U7 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
Show all
 294 aa
32.8 kDa 		No 0
ACSL1-011
ENSP00000422607
ENST00000515030
P33121 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 1
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001676 [long-chain fatty acid metabolic process]
GO:0003824 [catalytic activity]
GO:0004467 [long-chain fatty acid-CoA ligase activity]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005778 [peroxisomal membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006631 [fatty acid metabolic process]
GO:0006641 [triglyceride metabolic process]
GO:0007584 [response to nutrient]
GO:0008152 [metabolic process]
GO:0008610 [lipid biosynthetic process]
GO:0010033 [response to organic substance]
GO:0014070 [response to organic cyclic compound]
GO:0015908 [fatty acid transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0033211 [adiponectin-activated signaling pathway]
GO:0033559 [unsaturated fatty acid metabolic process]
GO:0034201 [response to oleic acid]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0036109 [alpha-linolenic acid metabolic process]
GO:0042178 [xenobiotic catabolic process]
GO:0042493 [response to drug]
GO:0043651 [linoleic acid metabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044539 [long-chain fatty acid import]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
Show all
 698 aa
77.9 kDa 		No 2
ACSL1-201
ENSP00000485264
ENST00000622937
B7Z3Z9 [Direct mapping]
Long-chain-fatty-acid--CoA ligase 1; cDNA FLJ53511, highly similar to Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3)
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
GO:0016874 [ligase activity]
Show all
 527 aa
58.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.