Expression of SLC25A4 in cancer - Summary

GENERAL INFORMATION
Gene name	SLC25A4
Gene description	Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
Protein class	Disease related genes FDA approved drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (heart muscle, skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in several tissues, highly abundant in heart, parathyroid gland and gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA071684
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA071684

GENE INFORMATION
Gene name	SLC25A4 (HGNC Symbol)
Synonyms	ANT1, PEO2, PEO3, T1
Description	Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 (HGNC Symbol)
Entrez gene summary	This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Mutations in this gene have been shown to result in autosomal dominant progressive external opthalmoplegia and familial hypertrophic cardiomyopathy. [provided by RefSeq, Jun 2013]
Chromosome	4
Cytoband	q35.1
Chromosome location (bp)	185143241 - 185150382
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151729 (version 83.38)
Entrez gene	291
UniProt	P12235 (UniProt - Evidence at protein level)
neXtProt	NX_P12235
Antibodypedia	SLC25A4 antibodies

PROTEIN BROWSER

SLC25A4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC25A4-001 ENSP00000281456 ENST00000281456	P12235 [Direct mapping] ADP/ATP translocase 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000002 [mitochondrial genome maintenance] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005887 [integral component of plasma membrane] GO:0006091 [generation of precursor metabolites and energy] GO:0006112 [energy reserve metabolic process] GO:0006810 [transport] GO:0008637 [apoptotic mitochondrial changes] GO:0015207 [adenine transmembrane transporter activity] GO:0015853 [adenine transport] GO:0016032 [viral process] GO:0043209 [myelin sheath] GO:0044281 [small molecule metabolic process] GO:0050796 [regulation of insulin secretion] GO:0055085 [transmembrane transport] GO:0060546 [negative regulation of necroptotic process] Show all	298 aa 33.1 kDa	No	3