Cell atlas - NBAS - The Human Protein Atlas

GENERAL INFORMATION
Gene name	NBAS
Gene description	Neuroblastoma amplified sequence
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the Golgi apparatus. In addition localized to the nucleoli & nuclear membrane.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (approved)
Additional location	In addition localized to the Nuclear membrane (approved), Nucleoli (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA036817
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ASSAYS

RNA expression

Human cells

Custom data

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the Golgi apparatus. In addition localized to the nucleoli & nuclear membrane.

Main location

Golgi apparatus (approved)

Additional location

Nuclear membrane (approved), Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA036817	A-431	Golgi apparatus
HPA036817	A-431	Cytosol
HPA036817	U-2 OS	Nuclear membrane
		Nucleoli
		Golgi apparatus
HPA036817	U-251 MG	Nuclear membrane
		Nucleoli
		Golgi apparatus
		Cytosol

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA036817	U-2 OS	Image	Co-localization with the cis-Golgi marker GM130/GOLGA2 (RRID:AB_398141) for a refined protein localization within the Golgi apparatus in U-2 OS cells. NBAS localizes to the Golgi apparatus, but not to the cis-Golgi compartment.

GENE INFORMATION
Gene name	NBAS (HGNC Symbol)
Synonyms	NAG
Description	Neuroblastoma amplified sequence (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with two leucine zipper domains, a ribosomal protein S14 signature domain and a Sec39 like domain. The protein is thought to be involved in Golgi-to-ER transport. Mutations in this gene are associated with short stature, optic nerve atrophy, and Pelger-Huet anomaly. [provided by RefSeq, Oct 2012]
Chromosome	2
Cytoband	p24.3
Chromosome location (bp)	15166909 - 15561330
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151779 (version 83.38)
Entrez gene	51594
UniProt	A2RRP1 (UniProt - Evidence at protein level)
neXtProt	NX_A2RRP1
Antibodypedia	NBAS antibodies

PROTEIN BROWSER

NBAS-001	NBAS-002	NBAS-003	NBAS-005	NBAS-006	NBAS-007	NBAS-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NBAS-001 ENSP00000281513 ENST00000281513	A2RRP1 [Direct mapping] Neuroblastoma-amplified sequence Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000149 [SNARE binding] GO:0000956 [nuclear-transcribed mRNA catabolic process] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0031965 [nuclear membrane] GO:0070939 [Dsl1p complex] GO:2000623 [negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] Show all	2371 aa 268.6 kDa	No	0
NBAS-002 ENSP00000398411 ENST00000442506	H0Y5G7 [Direct mapping] Neuroblastoma-amplified sequence Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005622 [intracellular] GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER] Show all	1419 aa 160.4 kDa	No	0
NBAS-003 ENSP00000392421 ENST00000417461	H7C007 [Direct mapping] Neuroblastoma-amplified sequence Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		171 aa 18.8 kDa	No	0
NBAS-005 ENSP00000390920 ENST00000433283	H7BZR3 [Direct mapping] Neuroblastoma-amplified sequence Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		184 aa 21 kDa	No	0
NBAS-006 ENSP00000403119 ENST00000423602	H7C1Y9 [Direct mapping] Neuroblastoma-amplified sequence Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		137 aa 15.9 kDa	No	0
NBAS-007 ENSP00000391476 ENST00000429842	H7BZU5 [Direct mapping] Neuroblastoma-amplified sequence Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER] GO:0016021 [integral component of membrane] Show all	204 aa 23.6 kDa	No	1
NBAS-008 ENSP00000396501 ENST00000441755	C9JCM7 [Direct mapping] Neuroblastoma-amplified sequence Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER] GO:0031965 [nuclear membrane] Show all	281 aa 32.2 kDa	No	0