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CENPJ

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GENERAL INFORMATION

Gene name

 CENPJ

Gene description

 Centromere protein J

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane, centrosome & nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (uncertain), Plasma membrane (uncertain), Centrosome (supported)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA060426
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane, centrosome & nucleoplasm.

Main location

 Nucleoplasm (uncertain), Plasma membrane (uncertain), Centrosome (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA060426 BJ Nucleoplasm
Plasma membrane
Centrosome
HPA060426 RH-30 Nucleoplasm
Plasma membrane
Centrosome
HPA060426 U-2 OS Nucleoplasm
Plasma membrane
Centrosome

GENE INFORMATION

Gene name

 CENPJ (HGNC Symbol)

Synonyms

 BM032, CPAP, LAP, LIP1, MCPH6, Sas-4, SASS4, SCKL4

Description

 Centromere protein J (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]

Chromosome

 13

Cytoband

Chromosome location (bp)

 24882284 - 24922889

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000151849 (version 83.38)

Entrez gene

 55835

UniProt

 Q9HC77 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HC77

Antibodypedia

 CENPJ antibodies

PROTEIN BROWSER
CENPJ-001
CENPJ-002
CENPJ-201
CENPJ-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CENPJ-001
ENSP00000371308
ENST00000381884
Q9HC77 [Direct mapping]
Centromere protein J
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007020 [microtubule nucleation]
GO:0007099 [centriole replication]
GO:0008275 [gamma-tubulin small complex]
GO:0015631 [tubulin binding]
GO:0019901 [protein kinase binding]
GO:0019904 [protein domain specific binding]
GO:0046599 [regulation of centriole replication]
GO:0046785 [microtubule polymerization]
GO:0051301 [cell division]
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 1338 aa
153 kDa 		No 0
CENPJ-002
ENSP00000399334
ENST00000418179
H0Y5L8 [Direct mapping]
Centromere protein J
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 196 aa
23.5 kDa 		No 0
CENPJ-201
ENSP00000441090
ENST00000545981
F6VUX8 [Direct mapping]
Centromere protein J
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 1136 aa
129.9 kDa 		No 0
CENPJ-202
ENSP00000477511
ENST00000616936
Q9HC77 [Direct mapping]
Centromere protein J
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007020 [microtubule nucleation]
GO:0007099 [centriole replication]
GO:0008275 [gamma-tubulin small complex]
GO:0015631 [tubulin binding]
GO:0019901 [protein kinase binding]
GO:0019904 [protein domain specific binding]
GO:0046599 [regulation of centriole replication]
GO:0046785 [microtubule polymerization]
GO:0051301 [cell division]
Show all
 1086 aa
124.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.