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ASTN1

GENERAL INFORMATION

Gene name

 ASTN1

Gene description

 Astrotactin 1

Protein class

 Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Cell line enhanced (Karpas-707, NTERA-2, U-2 OS, U-266/84)
HPA (normal tissue):Group enriched (adrenal gland, cerebral cortex)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 ASTN1 (HGNC Symbol)

Synonyms

 ASTN

Description

 Astrotactin 1 (HGNC Symbol)

Entrez gene summary

 Astrotactin is a neuronal adhesion molecule required for glial-guided migration of young postmitotic neuroblasts in cortical regions of developing brain, including cerebrum, hippocampus, cerebellum, and olfactory bulb (Fink et al., 1995).[supplied by OMIM, Jun 2009]

Chromosome

 1

Cytoband

 q25.2

Chromosome location (bp)

 176857302 - 177164973

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000152092 (version 83.38)

Entrez gene

 460

UniProt

 O14525 (UniProt - Evidence at transcript level)

neXtProt

 NX_O14525

Antibodypedia

 ASTN1 antibodies

PROTEIN BROWSER
ASTN1-001
ASTN1-002
ASTN1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ASTN1-001
ENSP00000354536
ENST00000361833
O14525 [Direct mapping]
Astrotactin-1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001764 [neuron migration]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005768 [endosome]
GO:0007158 [neuron cell-cell adhesion]
GO:0007626 [locomotory behavior]
GO:0009897 [external side of plasma membrane]
GO:0016021 [integral component of membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016477 [cell migration]
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 1294 aa
144 kDa 		Yes 2
ASTN1-002
ENSP00000356629
ENST00000367657
B1AJS1 [Direct mapping]
Astrotactin-1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
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 1228 aa
136.5 kDa 		Yes 2
ASTN1-003
ENSP00000395041
ENST00000424564
O14525 [Direct mapping]
Astrotactin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
Show all
 1216 aa
135.1 kDa 		Yes 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.