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Colorectal cancers displayed moderate to strong membranous positivity. Few cases of breast, ovary, thyroid, skin and testicular cancers were moderately stained. Remaining cancer tissues were weakly stained or negative.
Cancer cells displayed moderate cytoplasmic immunoreactivity. Several cases of colorectal, breast and cervical cancers showed strong cytoplasmic staining. Most cases of lymphomas and urothelial cancers were weakly stained or negative.
Strong cytoplasmic positivity, with a granular pattern was displayed in several pancreatic and stomach cancers. Remaining cancer tissues were weakly stained or mainly negative.
GENE INFORMATION
Gene name
PTPN14 (HGNC Symbol)
Synonyms
PEZ
Description
Protein tyrosine phosphatase, non-receptor type 14 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010]
Q15678 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 14
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Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)