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POU4F1

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GENERAL INFORMATION

Gene name

 POU4F1

Gene description

 POU class 4 homeobox 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (SCLC-21H, RH-30, HEL, HEK 293, U-266/70)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, RH-30, HEL, HEK 293, U-266/70)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 POU4F1 (HGNC Symbol)

Synonyms

 BRN3A, RDC-1

Description

 POU class 4 homeobox 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the POU-IV class of neural transcription factors. This protein is expressed in a subset of retinal ganglion cells and may be involved in the developing sensory nervous system. This protein may also promote the growth of cervical tumors. A translocation of this gene is associated with some adult acute myeloid leukemias. [provided by RefSeq, Mar 2012]

Chromosome

 13

Cytoband

 q31.1

Chromosome location (bp)

 78598362 - 78603560

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000152192 (version 83.38)

Entrez gene

 5457

UniProt

 Q01851 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q01851

Antibodypedia

 POU4F1 antibodies

PROTEIN BROWSER
POU4F1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POU4F1-001
ENSP00000366413
ENST00000377208
Q01851 [Direct mapping]
POU domain, class 4, transcription factor 1
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0001967 [suckling behavior]
GO:0003223 [ventricular compact myocardium morphogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007399 [nervous system development]
GO:0007409 [axonogenesis]
GO:0007416 [synapse assembly]
GO:0007498 [mesoderm development]
GO:0021535 [cell migration in hindbrain]
GO:0021559 [trigeminal nerve development]
GO:0021953 [central nervous system neuron differentiation]
GO:0021986 [habenula development]
GO:0030182 [neuron differentiation]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048665 [neuron fate specification]
GO:0048880 [sensory system development]
GO:0048934 [peripheral nervous system neuron differentiation]
GO:0048935 [peripheral nervous system neuron development]
GO:0050767 [regulation of neurogenesis]
GO:0051355 [proprioception involved in equilibrioception]
GO:0060384 [innervation]
GO:0071158 [positive regulation of cell cycle arrest]
GO:2001208 [negative regulation of transcription elongation from RNA polymerase I promoter]
Show all
 419 aa
42.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.