Expression of CYSLTR2 in cancer - Summary - The Human Protein Atlas

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CYSLTR2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CYSLTR2
Gene description	Cysteinyl leukotriene receptor 2
Protein class	FDA approved drug targets G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (melanoma, renal cancer, thyroid cancer)
HPA (cell line):	Cell line enriched (HDLM-2)
HPA (normal tissue):	Tissue enhanced (placenta, seminal vesicle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA046528
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (melanoma, renal cancer, thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046528

GENE INFORMATION
Gene name	CYSLTR2 (HGNC Symbol)
Synonyms	CysLT(2), CYSLT2R
Description	Cysteinyl leukotriene receptor 2 (HGNC Symbol)
Entrez gene summary	The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008]
Chromosome	13
Cytoband	q14.2
Chromosome location (bp)	48653711 - 48711226
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000152207 (version 83.38)
Entrez gene	57105
UniProt	Q9NS75 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NS75
Antibodypedia	CYSLTR2 antibodies

PROTEIN BROWSER

CYSLTR2-001	CYSLTR2-002	CYSLTR2-003	CYSLTR2-004	CYSLTR2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CYSLTR2-001 ENSP00000282018 ENST00000282018	Q9NS75 [Direct mapping] Cysteinyl leukotriene receptor 2 Q5KU17 [Target identity:100%; Query identity:100%] Cysteinyl leukotriene receptor 2; G-protein coupled receptor protein; cDNA FLJ78284, highly similar to Homo sapiens cysteinyl leukotriene receptor 2 (CYSLTR2), mRNA Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0001631 [cysteinyl leukotriene receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004974 [leukotriene receptor activity] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0008528 [G-protein coupled peptide receptor activity] GO:0010942 [positive regulation of cell death] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0045766 [positive regulation of angiogenesis] GO:0061737 [leukotriene signaling pathway] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] Show all	346 aa 39.6 kDa	No	7
CYSLTR2-002 ENSP00000477930 ENST00000614739	Q9NS75 [Direct mapping] Cysteinyl leukotriene receptor 2 Q5KU17 [Target identity:100%; Query identity:100%] Cysteinyl leukotriene receptor 2; G-protein coupled receptor protein; cDNA FLJ78284, highly similar to Homo sapiens cysteinyl leukotriene receptor 2 (CYSLTR2), mRNA Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0001631 [cysteinyl leukotriene receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004974 [leukotriene receptor activity] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0008528 [G-protein coupled peptide receptor activity] GO:0016021 [integral component of membrane] GO:0061737 [leukotriene signaling pathway] Show all	346 aa 39.6 kDa	No	7
CYSLTR2-003 ENSP00000482041 ENST00000617562	A4ZKH2 [Direct mapping] Cysteinyl leukotriene receptor 2; Cysteinyl leukotriene receptor 2 splice variant I; Cysteinyl leukotriene receptor 2 splice variant II; Cysteinyl leukotriene receptor 2 splice variant III; Cysteinyl leukotriene receptor 2 splice variant IV; Cysteinyl leukotriene receptor 2 splice variant V; Cysteinyl leukotriene receptor 2 splice variant VI; Cysteinyl leukotriene receptor 2 splice variant VII; Cysteinyl leukotriene receptor 2 splice variant VIII Show all	Predicted intracellular proteins Show all		15 aa 1.7 kDa	No	0
CYSLTR2-004 ENSP00000479446 ENST00000622559	A4ZKH2 [Direct mapping] Cysteinyl leukotriene receptor 2; Cysteinyl leukotriene receptor 2 splice variant I; Cysteinyl leukotriene receptor 2 splice variant II; Cysteinyl leukotriene receptor 2 splice variant III; Cysteinyl leukotriene receptor 2 splice variant IV; Cysteinyl leukotriene receptor 2 splice variant V; Cysteinyl leukotriene receptor 2 splice variant VI; Cysteinyl leukotriene receptor 2 splice variant VII; Cysteinyl leukotriene receptor 2 splice variant VIII Show all	Predicted intracellular proteins Show all		15 aa 1.7 kDa	No	0
CYSLTR2-005 ENSP00000482031 ENST00000621321	A4ZKH2 [Direct mapping] Cysteinyl leukotriene receptor 2; Cysteinyl leukotriene receptor 2 splice variant I; Cysteinyl leukotriene receptor 2 splice variant II; Cysteinyl leukotriene receptor 2 splice variant III; Cysteinyl leukotriene receptor 2 splice variant IV; Cysteinyl leukotriene receptor 2 splice variant V; Cysteinyl leukotriene receptor 2 splice variant VI; Cysteinyl leukotriene receptor 2 splice variant VII; Cysteinyl leukotriene receptor 2 splice variant VIII Show all	Predicted intracellular proteins Show all		15 aa 1.7 kDa	No	0

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