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ATP5A1

GENERAL INFORMATION

Gene name

 ATP5A1

Gene description

 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression with a granular pattern in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA040622 , HPA044202 , CAB013067
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040622
HPA044202
CAB013067

GENE INFORMATION

Gene name

 ATP5A1 (HGNC Symbol)

Synonyms

 ATP5A, ATP5AL2, ATPM, hATP1, OMR, ORM

Description

 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, using an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the alpha subunit of the catalytic core. Alternatively spliced transcript variants encoding the different isoforms have been identified. Pseudogenes of this gene are located on chromosomes 9, 2, and 16. [provided by RefSeq, Mar 2012]

Chromosome

 18

Cytoband

 q21.1

Chromosome location (bp)

 46080248 - 46104334

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000152234 (version 83.38)

Entrez gene

 498

UniProt

 P25705 (UniProt - Evidence at protein level)

neXtProt

 NX_P25705

Antibodypedia

 ATP5A1 antibodies

PROTEIN BROWSER
ATP5A1-001
ATP5A1-003
ATP5A1-004
ATP5A1-005
ATP5A1-009
ATP5A1-016
ATP5A1-018
ATP5A1-201
ATP5A1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP5A1-001
ENSP00000381736
ENST00000398752
P25705 [Direct mapping]
ATP synthase subunit alpha, mitochondrial
V9HW26 [Target identity:100%; Query identity:100%]
ATP synthase subunit alpha
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005753 [mitochondrial proton-transporting ATP synthase complex]
GO:0005759 [mitochondrial matrix]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006754 [ATP biosynthetic process]
GO:0008180 [COP9 signalosome]
GO:0009790 [embryo development]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0015992 [proton transport]
GO:0016020 [membrane]
GO:0016820 [hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances]
GO:0016887 [ATPase activity]
GO:0022857 [transmembrane transporter activity]
GO:0022904 [respiratory electron transport chain]
GO:0033178 [proton-transporting two-sector ATPase complex, catalytic domain]
GO:0042288 [MHC class I protein binding]
GO:0042776 [mitochondrial ATP synthesis coupled proton transport]
GO:0043209 [myelin sheath]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045261 [proton-transporting ATP synthase complex, catalytic core F(1)]
GO:0046034 [ATP metabolic process]
GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0070062 [extracellular exosome]
Show all
 553 aa
59.7 kDa 		No 0
ATP5A1-003
ENSP00000465497
ENST00000589869
K7EK77 [Direct mapping]
ATP synthase subunit alpha, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0015992 [proton transport]
GO:0045261 [proton-transporting ATP synthase complex, catalytic core F(1)]
GO:0046034 [ATP metabolic process]
GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
Show all
 207 aa
22.2 kDa 		No 0
ATP5A1-004
ENSP00000465259
ENST00000590324
K7EJP1 [Direct mapping]
ATP synthase subunit alpha, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0015986 [ATP synthesis coupled proton transport]
GO:0015992 [proton transport]
GO:0045261 [proton-transporting ATP synthase complex, catalytic core F(1)]
GO:0046034 [ATP metabolic process]
GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
Show all
 145 aa
15.3 kDa 		No 0
ATP5A1-005
ENSP00000468458
ENST00000590406
K7ERX7 [Direct mapping]
ATP synthase subunit alpha, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0015986 [ATP synthesis coupled proton transport]
GO:0015992 [proton transport]
GO:0045261 [proton-transporting ATP synthase complex, catalytic core F(1)]
GO:0046034 [ATP metabolic process]
GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
Show all
 205 aa
21.6 kDa 		No 0
ATP5A1-009
ENSP00000467037
ENST00000590665
P25705 [Direct mapping]
ATP synthase subunit alpha, mitochondrial
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005753 [mitochondrial proton-transporting ATP synthase complex]
GO:0005759 [mitochondrial matrix]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006754 [ATP biosynthetic process]
GO:0008180 [COP9 signalosome]
GO:0009790 [embryo development]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0015992 [proton transport]
GO:0016020 [membrane]
GO:0016820 [hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances]
GO:0016887 [ATPase activity]
GO:0022857 [transmembrane transporter activity]
GO:0022904 [respiratory electron transport chain]
GO:0033178 [proton-transporting two-sector ATPase complex, catalytic domain]
GO:0042288 [MHC class I protein binding]
GO:0042776 [mitochondrial ATP synthesis coupled proton transport]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045261 [proton-transporting ATP synthase complex, catalytic core F(1)]
GO:0046034 [ATP metabolic process]
GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0070062 [extracellular exosome]
Show all
 531 aa
57.5 kDa 		No 0
ATP5A1-016
ENSP00000467830
ENST00000592989
K7EQH4 [Direct mapping]
ATP synthase subunit alpha, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0015986 [ATP synthesis coupled proton transport]
GO:0015992 [proton transport]
GO:0045261 [proton-transporting ATP synthase complex, catalytic core F(1)]
GO:0046034 [ATP metabolic process]
GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
Show all
 111 aa
11.7 kDa 		No 0
ATP5A1-018
ENSP00000466975
ENST00000589252
K7ENJ4 [Direct mapping]
ATP synthase subunit alpha, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0045261 [proton-transporting ATP synthase complex, catalytic core F(1)]
GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
Show all
 199 aa
21.3 kDa 		No 0
ATP5A1-201
ENSP00000282050
ENST00000282050
P25705 [Direct mapping]
ATP synthase subunit alpha, mitochondrial
V9HW26 [Target identity:100%; Query identity:100%]
ATP synthase subunit alpha
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005753 [mitochondrial proton-transporting ATP synthase complex]
GO:0005759 [mitochondrial matrix]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006754 [ATP biosynthetic process]
GO:0008180 [COP9 signalosome]
GO:0009790 [embryo development]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0015992 [proton transport]
GO:0016020 [membrane]
GO:0016820 [hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances]
GO:0016887 [ATPase activity]
GO:0022857 [transmembrane transporter activity]
GO:0022904 [respiratory electron transport chain]
GO:0033178 [proton-transporting two-sector ATPase complex, catalytic domain]
GO:0042288 [MHC class I protein binding]
GO:0042776 [mitochondrial ATP synthesis coupled proton transport]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045261 [proton-transporting ATP synthase complex, catalytic core F(1)]
GO:0046034 [ATP metabolic process]
GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0070062 [extracellular exosome]
Show all
 553 aa
59.7 kDa 		No 0
ATP5A1-202
ENSP00000465477
ENST00000593152
P25705 [Direct mapping]
ATP synthase subunit alpha, mitochondrial
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005753 [mitochondrial proton-transporting ATP synthase complex]
GO:0005759 [mitochondrial matrix]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006754 [ATP biosynthetic process]
GO:0008180 [COP9 signalosome]
GO:0009790 [embryo development]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0015992 [proton transport]
GO:0016020 [membrane]
GO:0016820 [hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances]
GO:0016887 [ATPase activity]
GO:0022857 [transmembrane transporter activity]
GO:0022904 [respiratory electron transport chain]
GO:0033178 [proton-transporting two-sector ATPase complex, catalytic domain]
GO:0042288 [MHC class I protein binding]
GO:0042776 [mitochondrial ATP synthesis coupled proton transport]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045261 [proton-transporting ATP synthase complex, catalytic core F(1)]
GO:0046034 [ATP metabolic process]
GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0070062 [extracellular exosome]
Show all
 503 aa
54.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.