Tissue expression of G6PC2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	G6PC2
Gene description	Glucose-6-phosphatase, catalytic, 2
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (pancreas)
GTEx:	Tissue enriched (pancreas)
FANTOM5:	Group enriched (pancreas, retina)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (pancreas)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (pancreas)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (pancreas, retina)

GENE INFORMATION
Gene name	G6PC2 (HGNC Symbol)
Synonyms	IGRP
Description	Glucose-6-phosphatase, catalytic, 2 (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme belonging to the glucose-6-phosphatase catalytic subunit family. These enzymes are part of a multicomponent integral membrane system that catalyzes the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, allowing the release of glucose into the bloodstream. The family member encoded by this gene is found in pancreatic islets and does not exhibit phosphohydrolase activity, but it is a major target of cell-mediated autoimmunity in diabetes. Several alternatively spliced transcript variants of this gene have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q31.1
Chromosome location (bp)	168901240 - 168910000
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000152254 (version 83.38)
Entrez gene	57818
UniProt	Q9NQR9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NQR9
Antibodypedia	G6PC2 antibodies

PROTEIN BROWSER

G6PC2-001	G6PC2-004	G6PC2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
G6PC2-001 ENSP00000364512 ENST00000375363	Q9NQR9 [Direct mapping] Glucose-6-phosphatase 2 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Show all	GO:0004346 [glucose-6-phosphatase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005975 [carbohydrate metabolic process] GO:0006094 [gluconeogenesis] GO:0008645 [hexose transport] GO:0015758 [glucose transport] GO:0016020 [membrane] GO:0016311 [dephosphorylation] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0042593 [glucose homeostasis] GO:0044281 [small molecule metabolic process] GO:0050796 [regulation of insulin secretion] GO:0051156 [glucose 6-phosphate metabolic process] GO:0055085 [transmembrane transport] Show all	355 aa 40.6 kDa	No	8
G6PC2-004 ENSP00000396939 ENST00000429379	Q9NQR9 [Direct mapping] Glucose-6-phosphatase 2 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0004346 [glucose-6-phosphatase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005975 [carbohydrate metabolic process] GO:0006094 [gluconeogenesis] GO:0008645 [hexose transport] GO:0015758 [glucose transport] GO:0016020 [membrane] GO:0016311 [dephosphorylation] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0042593 [glucose homeostasis] GO:0044281 [small molecule metabolic process] GO:0050796 [regulation of insulin secretion] GO:0051156 [glucose 6-phosphate metabolic process] GO:0055085 [transmembrane transport] Show all	154 aa 17.8 kDa	No	2
G6PC2-005 ENSP00000392183 ENST00000421979	C9IYU7 [Direct mapping] Glucose-6-phosphatase 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004346 [glucose-6-phosphatase activity] GO:0006094 [gluconeogenesis] GO:0016020 [membrane] GO:0016311 [dephosphorylation] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0051156 [glucose 6-phosphate metabolic process] Show all	80 aa 9.5 kDa	No	0