Expression of PDK1 in cancer - Summary - The Human Protein Atlas

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PDK1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PDK1
Gene description	Pyruvate dehydrogenase kinase, isozyme 1
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA027376 , CAB017554
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and cervical cancer (unfavourable).
Renal cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA027376	CAB017554

GENE INFORMATION
Gene name	PDK1
Synonyms
Description	Pyruvate dehydrogenase kinase, isozyme 1 (HGNC Symbol)
Entrez gene summary	Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013]
Chromosome	2
Cytoband	q31.1
Chromosome location (bp)	172555373 - 172608669
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000152256 (version 83.38)
Entrez gene	5163
UniProt	Q15118 (UniProt - Evidence at protein level)
neXtProt	NX_Q15118
Antibodypedia	PDK1 antibodies

PROTEIN BROWSER

PDK1-001	PDK1-002	PDK1-003	PDK1-004	PDK1-007	PDK1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDK1-001 ENSP00000282077 ENST00000282077	Q15118 [Direct mapping] [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial Show all	Enzymes ENZYME proteins Transferases Kinases Atypical kinases Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004740 [pyruvate dehydrogenase (acetyl-transferring) kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006006 [glucose metabolic process] GO:0006090 [pyruvate metabolic process] GO:0006468 [protein phosphorylation] GO:0008283 [cell proliferation] GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress] GO:0010510 [regulation of acetyl-CoA biosynthetic process from pyruvate] GO:0010906 [regulation of glucose metabolic process] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0097411 [hypoxia-inducible factor-1alpha signaling pathway] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	436 aa 49.2 kDa	No	0
PDK1-002 ENSP00000386985 ENST00000410055	Q15118 [Direct mapping] [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial Show all	Enzymes ENZYME proteins Transferases Kinases Atypical kinases Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004740 [pyruvate dehydrogenase (acetyl-transferring) kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006006 [glucose metabolic process] GO:0006090 [pyruvate metabolic process] GO:0006468 [protein phosphorylation] GO:0008283 [cell proliferation] GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress] GO:0010510 [regulation of acetyl-CoA biosynthetic process from pyruvate] GO:0010906 [regulation of glucose metabolic process] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0097411 [hypoxia-inducible factor-1alpha signaling pathway] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	436 aa 49.2 kDa	No	0
PDK1-003 ENSP00000376352 ENST00000392571	Q15118 [Direct mapping] [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial Show all	Enzymes ENZYME proteins Transferases Kinases Atypical kinases SCAMPI predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004740 [pyruvate dehydrogenase (acetyl-transferring) kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005967 [mitochondrial pyruvate dehydrogenase complex] GO:0006006 [glucose metabolic process] GO:0006090 [pyruvate metabolic process] GO:0006468 [protein phosphorylation] GO:0008283 [cell proliferation] GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress] GO:0010510 [regulation of acetyl-CoA biosynthetic process from pyruvate] GO:0010906 [regulation of glucose metabolic process] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0097411 [hypoxia-inducible factor-1alpha signaling pathway] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	456 aa 51.6 kDa	No	0
PDK1-004 ENSP00000399558 ENST00000443353	C9JKT3 [Direct mapping] [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		154 aa 17.8 kDa	No	0
PDK1-007 ENSP00000388366 ENST00000439519	C9JKT3 [Direct mapping] [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		154 aa 17.8 kDa	No	0
PDK1-008 ENSP00000399160 ENST00000416991	C9IYB4 [Direct mapping] [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		229 aa 26.3 kDa	No	0

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The Human Protein Atlas

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