Cell atlas - KCNK13 - The Human Protein Atlas

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KCNK13

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cell Junctions
	Nuclear speckles

Human cell
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	KCNK13
Gene description	Potassium channel, two pore domain subfamily K, member 13
Protein class	Predicted membrane proteins Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cell junctions & nuclear speckles.
RNA cell category	Cell line enhanced (RT4)
Protein evidence	Evidence at transcript level
Main location	Localized to the Nuclear speckles (approved), Cell Junctions (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA003514
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RT4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cell junctions & nuclear speckles.

Main location

Nuclear speckles (approved), Cell Junctions (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA003514	RT4	Nuclear speckles
	HPA003514	RT4	Cell Junctions
	HPA003514	U-2 OS	No staining

GENE INFORMATION
Gene name	KCNK13 (HGNC Symbol)
Synonyms	K2p13.1, THIK-1, THIK1
Description	Potassium channel, two pore domain subfamily K, member 13 (HGNC Symbol)
Entrez gene summary	Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a potassium channel containing two pore-forming domains. This protein is an open channel that can be stimulated by arachidonic acid and inhibited by the anesthetic halothane. [provided by RefSeq, Jul 2013]
Chromosome	14
Cytoband	q32.11
Chromosome location (bp)	90061765 - 90185857
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000152315 (version 83.38)
Entrez gene	56659
UniProt	Q9HB14 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9HB14
Antibodypedia	KCNK13 antibodies

PROTEIN BROWSER

KCNK13-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNK13-001 ENSP00000282146 ENST00000282146	Q9HB14 [Direct mapping] Potassium channel subfamily K member 13 Show all	Voltage-gated ion channels Two-P Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005244 [voltage-gated ion channel activity] GO:0005267 [potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007268 [synaptic transmission] GO:0022841 [potassium ion leak channel activity] GO:0030322 [stabilization of membrane potential] GO:0034765 [regulation of ion transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	408 aa 45.4 kDa	No	6

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.