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SPOCK1

GENERAL INFORMATION

Gene name

 SPOCK1

Gene description

 Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (prostate cancer)
HPA (cell line):Cell line enhanced (AF22, HUVEC TERT2, U-138 MG)
HPA (normal tissue):Tissue enhanced (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Uncertain based on 1 antibody.
HPA007450
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable), renal cancer (unfavourable), colorectal cancer (unfavourable), ovarian cancer (unfavourable), lung cancer (unfavourable) and stomach cancer (unfavourable).
Head and neck cancer p<0.001
Renal cancer p<0.001
Colorectal cancer p<0.001
Ovarian cancer p<0.001
Lung cancer p<0.001
Stomach cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (prostate cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA007450

GENE INFORMATION

Gene name

 SPOCK1 (HGNC Symbol)

Synonyms

 SPOCK, testican-1, TIC1

Description

 Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its function may be related to protease inhibition. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q31.2

Chromosome location (bp)

 136975298 - 137598379

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000152377 (version 83.38)

Entrez gene

 6695

UniProt

 Q08629 (UniProt - Evidence at protein level)

neXtProt

 NX_Q08629

Antibodypedia

 SPOCK1 antibodies

PROTEIN BROWSER
SPOCK1-001
SPOCK1-003
SPOCK1-004
SPOCK1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SPOCK1-001
ENSP00000378401
ENST00000394945
Q08629 [Direct mapping]
Testican-1
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001558 [regulation of cell growth]
GO:0001764 [neuron migration]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0004869 [cysteine-type endopeptidase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0008191 [metalloendopeptidase inhibitor activity]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0010977 [negative regulation of neuron projection development]
GO:0014069 [postsynaptic density]
GO:0016528 [sarcoplasm]
GO:0021953 [central nervous system neuron differentiation]
GO:0022008 [neurogenesis]
GO:0031594 [neuromuscular junction]
GO:0033268 [node of Ranvier]
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 439 aa
49.1 kDa 		Yes 0
SPOCK1-003
ENSP00000424517
ENST00000505690
D6RB21 [Direct mapping]
Testican-1
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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 139 aa
15.8 kDa 		Yes 0
SPOCK1-004
ENSP00000421677
ENST00000510689
D6RAM7 [Direct mapping]
Testican-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 67 aa
7.3 kDa 		No 0
SPOCK1-201
ENSP00000282223
ENST00000282223
A0A0A0MQX7 [Direct mapping]
Testican-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0007165 [signal transduction]
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 377 aa
42.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.