Cell atlas - GUCY1A2 - The Human Protein Atlas

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GUCY1A2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	GUCY1A2
Gene description	Guanylate cyclase 1, soluble, alpha 2
Protein class	Enzymes FDA approved drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V, BJ hTERT+, HBF TERT88)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V, BJ hTERT+, HBF TERT88) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	GUCY1A2 (HGNC Symbol)
Synonyms	GC-SA2, GUC1A2
Description	Guanylate cyclase 1, soluble, alpha 2 (HGNC Symbol)
Entrez gene summary	Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Chromosome	11
Cytoband	q22.3
Chromosome location (bp)	106674012 - 107018524
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000152402 (version 83.38)
Entrez gene	2977
UniProt	P33402 (UniProt - Evidence at transcript level)
neXtProt	NX_P33402
Antibodypedia	GUCY1A2 antibodies

PROTEIN BROWSER

GUCY1A2-001	GUCY1A2-002	GUCY1A2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GUCY1A2-001 ENSP00000431245 ENST00000526355	P33402 [Direct mapping] Guanylate cyclase soluble subunit alpha-2 Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0004383 [guanylate cyclase activity] GO:0005525 [GTP binding] GO:0005886 [plasma membrane] GO:0006182 [cGMP biosynthetic process] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] GO:0008074 [guanylate cyclase complex, soluble] GO:0009190 [cyclic nucleotide biosynthetic process] GO:0016849 [phosphorus-oxygen lyase activity] GO:0020037 [heme binding] GO:0035556 [intracellular signal transduction] Show all	732 aa 81.7 kDa	No	0
GUCY1A2-002 ENSP00000282249 ENST00000282249	P33402 [Direct mapping] Guanylate cyclase soluble subunit alpha-2 Show all	Enzymes ENZYME proteins Lyases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0004383 [guanylate cyclase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005886 [plasma membrane] GO:0006182 [cGMP biosynthetic process] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] GO:0008074 [guanylate cyclase complex, soluble] GO:0009190 [cyclic nucleotide biosynthetic process] GO:0016849 [phosphorus-oxygen lyase activity] GO:0020037 [heme binding] GO:0030828 [positive regulation of cGMP biosynthetic process] GO:0035556 [intracellular signal transduction] Show all	763 aa 85.3 kDa	No	0
GUCY1A2-003 ENSP00000344874 ENST00000347596	P33402 [Direct mapping] Guanylate cyclase soluble subunit alpha-2 Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins FDA approved drug targets Small molecule drugs Show all	GO:0004383 [guanylate cyclase activity] GO:0005525 [GTP binding] GO:0005886 [plasma membrane] GO:0006182 [cGMP biosynthetic process] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] GO:0008074 [guanylate cyclase complex, soluble] GO:0009190 [cyclic nucleotide biosynthetic process] GO:0016849 [phosphorus-oxygen lyase activity] GO:0020037 [heme binding] GO:0035556 [intracellular signal transduction] Show all	753 aa 84 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.