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NMT2

GENERAL INFORMATION

Gene name

 NMT2

Gene description

 N-myristoyltransferase 2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (TIME)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA001303
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001303

GENE INFORMATION

Gene name

 NMT2

Synonyms

Description

 N-myristoyltransferase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes one of two N-myristoyltransferase proteins. N-terminal myristoylation is a lipid modification that is involved in regulating the function and localization of signaling proteins. The encoded protein catalyzes the addition of a myristoyl group to the N-terminal glycine residue of many signaling proteins, including the human immunodeficiency virus type 1 (HIV-1) proteins, Gag and Nef. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Chromosome

 10

Cytoband

 p13

Chromosome location (bp)

 15102584 - 15168693

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000152465 (version 83.38)

Entrez gene

 9397

UniProt

 O60551 (UniProt - Evidence at protein level)

neXtProt

 NX_O60551

Antibodypedia

 NMT2 antibodies

PROTEIN BROWSER
NMT2-001
NMT2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NMT2-001
ENSP00000367407
ENST00000378165
O60551 [Direct mapping]
Glycylpeptide N-tetradecanoyltransferase 2
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004379 [glycylpeptide N-tetradecanoyltransferase activity]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006499 [N-terminal protein myristoylation]
GO:0007603 [phototransduction, visible light]
GO:0016032 [viral process]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0018008 [N-terminal peptidyl-glycine N-myristoylation]
GO:0019068 [virion assembly]
GO:0019082 [viral protein processing]
GO:0019898 [extrinsic component of membrane]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0075733 [intracellular transport of virus]
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 498 aa
57 kDa 		No 0
NMT2-002
ENSP00000367392
ENST00000378150
Q5VUC6 [Direct mapping]
Glycylpeptide N-tetradecanoyltransferase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004379 [glycylpeptide N-tetradecanoyltransferase activity]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006499 [N-terminal protein myristoylation]
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 485 aa
56.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.