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PAN3

GENERAL INFORMATION

Gene name

 PAN3

Gene description

 PAN3 poly(A) specific ribonuclease subunit

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA028817
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA028817

GENE INFORMATION

Gene name

 PAN3

Synonyms

Description

 PAN3 poly(A) specific ribonuclease subunit (HGNC Symbol)

Entrez gene summary

Chromosome

 13

Cytoband

 q12.2

Chromosome location (bp)

 28138506 - 28295335

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000152520 (version 83.38)

Entrez gene

 255967

UniProt

 Q58A45 (UniProt - Evidence at protein level)

neXtProt

 NX_Q58A45

Antibodypedia

 PAN3 antibodies

PROTEIN BROWSER
PAN3-001
PAN3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PAN3-001
ENSP00000382522
ENST00000399613
A0A0C4DFZ9 [Direct mapping]
PAB-dependent poly(A)-specific ribonuclease subunit PAN3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006397 [mRNA processing]
GO:0006468 [protein phosphorylation]
GO:0010606 [positive regulation of cytoplasmic mRNA processing body assembly]
GO:0031251 [PAN complex]
GO:0044822 [poly(A) RNA binding]
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 687 aa
76 kDa 		No 0
PAN3-002
ENSP00000370345
ENST00000380958
Q58A45 [Direct mapping]
PAB-dependent poly(A)-specific ribonuclease subunit PAN3
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Enzymes
   Kinases
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0000290 [deadenylation-dependent decapping of nuclear-transcribed mRNA]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0004535 [poly(A)-specific ribonuclease activity]
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006397 [mRNA processing]
GO:0006468 [protein phosphorylation]
GO:0006605 [protein targeting]
GO:0010467 [gene expression]
GO:0010606 [positive regulation of cytoplasmic mRNA processing body assembly]
GO:0031251 [PAN complex]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
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 887 aa
95.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.