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DSPP

GENERAL INFORMATION

Gene name

 DSPP

Gene description

 Dentin sialophosphoprotein

Protein class

 Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Not detected

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Antibody staining not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA036230
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036230

GENE INFORMATION

Gene name

 DSPP (HGNC Symbol)

Synonyms

 DFNA39, DGI1, DMP3

Description

 Dentin sialophosphoprotein (HGNC Symbol)

Entrez gene summary

 This gene encodes two principal proteins of the dentin extracellular matrix of the tooth. The preproprotein is secreted by odontoblasts and cleaved into dentin sialoprotein and dentin phosphoprotein. Dentin phosphoprotein is thought to be involved in the biomineralization process of dentin. Mutations in this gene have been associated with dentinogenesis imperfecta-1; in some individuals, dentinogenesis imperfecta occurs in combination with an autosomal dominant form of deafness. Allelic differences due to repeat polymorphisms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q22.1

Chromosome location (bp)

 87608529 - 87616910

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000152591 (version 83.38)

Entrez gene

 1834

UniProt

 Q9NZW4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NZW4

Antibodypedia

 DSPP antibodies

PROTEIN BROWSER
DSPP-001
DSPP-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DSPP-001
ENSP00000282478
ENST00000282478
Q9NZW4 [Direct mapping]
Dentin sialophosphoprotein Dentin phosphoprotein Dentin sialoprotein
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
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GO:0001501 [skeletal system development]
GO:0001503 [ossification]
GO:0005201 [extracellular matrix structural constituent]
GO:0005509 [calcium ion binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005737 [cytoplasm]
GO:0007275 [multicellular organismal development]
GO:0030198 [extracellular matrix organization]
GO:0031214 [biomineral tissue development]
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 1301 aa
131.2 kDa 		Yes 0
DSPP-201
ENSP00000382213
ENST00000399271
Q9NZW4 [Direct mapping]
Dentin sialophosphoprotein Dentin phosphoprotein Dentin sialoprotein
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001503 [ossification]
GO:0005201 [extracellular matrix structural constituent]
GO:0005509 [calcium ion binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005737 [cytoplasm]
GO:0007275 [multicellular organismal development]
GO:0030198 [extracellular matrix organization]
GO:0031214 [biomineral tissue development]
GO:0071460 [cellular response to cell-matrix adhesion]
Show all
 1301 aa
131.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.