Expression of DMP1 in cancer - Summary - The Human Protein Atlas

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DMP1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DMP1
Gene description	Dentin matrix acidic phosphoprotein 1
Protein class	Disease related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Not detected

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several different tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	No RNA expression data detected and pending external verification.
Reliability score	Approved based on 1 antibody. HPA037465
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA037465

GENE INFORMATION
Gene name	DMP1
Synonyms
Description	Dentin matrix acidic phosphoprotein 1 (HGNC Symbol)
Entrez gene summary	Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q22.1
Chromosome location (bp)	87650307 - 87664361
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000152592 (version 83.38)
Entrez gene	1758
UniProt	Q13316 (UniProt - Evidence at protein level)
neXtProt	NX_Q13316
Antibodypedia	DMP1 antibodies

PROTEIN BROWSER

DMP1-001	DMP1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DMP1-001 ENSP00000340935 ENST00000339673	Q13316 [Direct mapping] Dentin matrix acidic phosphoprotein 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Show all	GO:0001503 [ossification] GO:0005178 [integrin binding] GO:0005509 [calcium ion binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0010811 [positive regulation of cell-substrate adhesion] GO:0030198 [extracellular matrix organization] GO:0031214 [biomineral tissue development] GO:0043231 [intracellular membrane-bounded organelle] GO:0050840 [extracellular matrix binding] Show all	513 aa 55.8 kDa	Yes	0
DMP1-002 ENSP00000282479 ENST00000282479	Q13316 [Direct mapping] Dentin matrix acidic phosphoprotein 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Show all	GO:0001503 [ossification] GO:0005178 [integrin binding] GO:0005509 [calcium ion binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0030198 [extracellular matrix organization] GO:0031214 [biomineral tissue development] GO:0043231 [intracellular membrane-bounded organelle] Show all	497 aa 54.1 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.