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SLC30A6

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GENERAL INFORMATION

Gene name

 SLC30A6

Gene description

 Solute carrier family 30 (zinc transporter), member 6

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the Golgi apparatus.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Golgi apparatus (validated)

Mouse

 Localized to the Golgi apparatus in mouse cells.

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA055032 , HPA057328
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ASSAYS
RNA expression
Human cells
Custom data
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the Golgi apparatus.

Main location

 Golgi apparatus (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA055032 A-431 Golgi apparatus
HPA055032 U-2 OS Golgi apparatus
HPA055032 U-251 MG Golgi apparatus
HPA057328 A-431 Golgi apparatus
HPA057328 U-2 OS Golgi apparatus
HPA057328 U-251 MG Golgi apparatus

CUSTOM DATA

 

 

 
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Thumbnail

Antibody

Cell line

Assay

Description
HPA057328 U-2 OS Image Co-localization with the cis-Golgi marker GM130/GOLGA2 (RRID:AB_398141) for a refined protein localization within the Golgi apparatus in U-2 OS cells. SLC30A6 localizes to the Golgi apparatus, but not to the cis-Golgi compartment.

MOUSE CELLS

Main location

 Golgi apparatus

Mouse gene

 ENSMUSG00000024069 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA055032 NIH 3T3 Golgi apparatus

GENE INFORMATION

Gene name

 SLC30A6 (HGNC Symbol)

Synonyms

 FLJ31101, ZNT6

Description

 Solute carrier family 30 (zinc transporter), member 6 (HGNC Symbol)

Entrez gene summary

 Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A6, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).[supplied by OMIM, Mar 2008]

Chromosome

 2

Cytoband

 p22.3

Chromosome location (bp)

 32165841 - 32224379

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000152683 (version 83.38)

Entrez gene

 55676

UniProt

 Q6NXT4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6NXT4

Antibodypedia

 SLC30A6 antibodies

PROTEIN BROWSER
SLC30A6-001
SLC30A6-002
SLC30A6-005
SLC30A6-006
SLC30A6-201
SLC30A6-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC30A6-001
ENSP00000282587
ENST00000282587
Q6NXT4 [Direct mapping]
Zinc transporter 6
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005385 [zinc ion transmembrane transporter activity]
GO:0005794 [Golgi apparatus]
GO:0006812 [cation transport]
GO:0008324 [cation transmembrane transporter activity]
GO:0010043 [response to zinc ion]
GO:0016021 [integral component of membrane]
GO:0044267 [cellular protein metabolic process]
GO:0055085 [transmembrane transport]
GO:0061088 [regulation of sequestering of zinc ion]
GO:0071577 [zinc II ion transmembrane transport]
Show all
 461 aa
51.1 kDa 		No 6
SLC30A6-002
ENSP00000368648
ENST00000379343
Q6NXT4 [Direct mapping]
Zinc transporter 6
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005385 [zinc ion transmembrane transporter activity]
GO:0005739 [mitochondrion]
GO:0005794 [Golgi apparatus]
GO:0006812 [cation transport]
GO:0008324 [cation transmembrane transporter activity]
GO:0010043 [response to zinc ion]
GO:0016021 [integral component of membrane]
GO:0044267 [cellular protein metabolic process]
GO:0055085 [transmembrane transport]
GO:0061088 [regulation of sequestering of zinc ion]
GO:0071577 [zinc II ion transmembrane transport]
Show all
 501 aa
55.8 kDa 		No 6
SLC30A6-005
ENSP00000384041
ENST00000406369
B5MCR8 [Direct mapping]
Solute carrier family 30 (Zinc transporter), member 6, isoform CRA_b; Zinc transporter 6
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005794 [Golgi apparatus]
GO:0006812 [cation transport]
GO:0008324 [cation transmembrane transporter activity]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
Show all
 387 aa
42.5 kDa 		No 4
SLC30A6-006
ENSP00000393946
ENST00000440718
C9JZR9 [Direct mapping]
Zinc transporter 6
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006812 [cation transport]
GO:0008324 [cation transmembrane transporter activity]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
Show all
 179 aa
20 kDa 		No 4
SLC30A6-201
ENSP00000349563
ENST00000357055
Q6NXT4 [Direct mapping]
Zinc transporter 6
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005385 [zinc ion transmembrane transporter activity]
GO:0005794 [Golgi apparatus]
GO:0006812 [cation transport]
GO:0008324 [cation transmembrane transporter activity]
GO:0010043 [response to zinc ion]
GO:0016021 [integral component of membrane]
GO:0044267 [cellular protein metabolic process]
GO:0055085 [transmembrane transport]
GO:0061088 [regulation of sequestering of zinc ion]
GO:0071577 [zinc II ion transmembrane transport]
Show all
 432 aa
47.6 kDa 		No 6
SLC30A6-202
ENSP00000399005
ENST00000435660
Q6NXT4 [Direct mapping]
Zinc transporter 6
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005385 [zinc ion transmembrane transporter activity]
GO:0005794 [Golgi apparatus]
GO:0006812 [cation transport]
GO:0008324 [cation transmembrane transporter activity]
GO:0010043 [response to zinc ion]
GO:0016021 [integral component of membrane]
GO:0044267 [cellular protein metabolic process]
GO:0055085 [transmembrane transport]
GO:0061088 [regulation of sequestering of zinc ion]
GO:0071577 [zinc II ion transmembrane transport]
Show all
 438 aa
48.6 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.