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SLC30A6

GENERAL INFORMATION

Gene name

 SLC30A6

Gene description

 Solute carrier family 30 (zinc transporter), member 6

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA057328
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and endometrial cancer (unfavourable).
Liver cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA057328

GENE INFORMATION

Gene name

 SLC30A6 (HGNC Symbol)

Synonyms

 FLJ31101, ZNT6

Description

 Solute carrier family 30 (zinc transporter), member 6 (HGNC Symbol)

Entrez gene summary

 Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A6, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).[supplied by OMIM, Mar 2008]

Chromosome

 2

Cytoband

 p22.3

Chromosome location (bp)

 32165841 - 32224379

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000152683 (version 83.38)

Entrez gene

 55676

UniProt

 Q6NXT4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6NXT4

Antibodypedia

 SLC30A6 antibodies

PROTEIN BROWSER
SLC30A6-001
SLC30A6-002
SLC30A6-005
SLC30A6-006
SLC30A6-201
SLC30A6-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC30A6-001
ENSP00000282587
ENST00000282587
Q6NXT4 [Direct mapping]
Zinc transporter 6
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005385 [zinc ion transmembrane transporter activity]
GO:0005794 [Golgi apparatus]
GO:0006812 [cation transport]
GO:0008324 [cation transmembrane transporter activity]
GO:0010043 [response to zinc ion]
GO:0016021 [integral component of membrane]
GO:0044267 [cellular protein metabolic process]
GO:0055085 [transmembrane transport]
GO:0061088 [regulation of sequestering of zinc ion]
GO:0071577 [zinc II ion transmembrane transport]
Show all
 461 aa
51.1 kDa 		No 6
SLC30A6-002
ENSP00000368648
ENST00000379343
Q6NXT4 [Direct mapping]
Zinc transporter 6
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005385 [zinc ion transmembrane transporter activity]
GO:0005739 [mitochondrion]
GO:0005794 [Golgi apparatus]
GO:0006812 [cation transport]
GO:0008324 [cation transmembrane transporter activity]
GO:0010043 [response to zinc ion]
GO:0016021 [integral component of membrane]
GO:0044267 [cellular protein metabolic process]
GO:0055085 [transmembrane transport]
GO:0061088 [regulation of sequestering of zinc ion]
GO:0071577 [zinc II ion transmembrane transport]
Show all
 501 aa
55.8 kDa 		No 6
SLC30A6-005
ENSP00000384041
ENST00000406369
B5MCR8 [Direct mapping]
Solute carrier family 30 (Zinc transporter), member 6, isoform CRA_b; Zinc transporter 6
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005794 [Golgi apparatus]
GO:0006812 [cation transport]
GO:0008324 [cation transmembrane transporter activity]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
Show all
 387 aa
42.5 kDa 		No 4
SLC30A6-006
ENSP00000393946
ENST00000440718
C9JZR9 [Direct mapping]
Zinc transporter 6
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006812 [cation transport]
GO:0008324 [cation transmembrane transporter activity]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
Show all
 179 aa
20 kDa 		No 4
SLC30A6-201
ENSP00000349563
ENST00000357055
Q6NXT4 [Direct mapping]
Zinc transporter 6
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005385 [zinc ion transmembrane transporter activity]
GO:0005794 [Golgi apparatus]
GO:0006812 [cation transport]
GO:0008324 [cation transmembrane transporter activity]
GO:0010043 [response to zinc ion]
GO:0016021 [integral component of membrane]
GO:0044267 [cellular protein metabolic process]
GO:0055085 [transmembrane transport]
GO:0061088 [regulation of sequestering of zinc ion]
GO:0071577 [zinc II ion transmembrane transport]
Show all
 432 aa
47.6 kDa 		No 6
SLC30A6-202
ENSP00000399005
ENST00000435660
Q6NXT4 [Direct mapping]
Zinc transporter 6
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005385 [zinc ion transmembrane transporter activity]
GO:0005794 [Golgi apparatus]
GO:0006812 [cation transport]
GO:0008324 [cation transmembrane transporter activity]
GO:0010043 [response to zinc ion]
GO:0016021 [integral component of membrane]
GO:0044267 [cellular protein metabolic process]
GO:0055085 [transmembrane transport]
GO:0061088 [regulation of sequestering of zinc ion]
GO:0071577 [zinc II ion transmembrane transport]
Show all
 438 aa
48.6 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.