Expression of ANKRD22 in cancer - Summary - The Human Protein Atlas

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ANKRD22

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ANKRD22
Gene description	Ankyrin repeat domain 22
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (CAPAN-2, RT4, T-47d)
HPA (normal tissue):	Tissue enhanced (skin, stomach)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in stomach and esophagus.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA012922
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and pancreatic cancer (unfavourable).
Endometrial cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA012922

GENE INFORMATION
Gene name	ANKRD22 (HGNC Symbol)
Synonyms	MGC22805
Description	Ankyrin repeat domain 22 (HGNC Symbol)
Entrez gene summary
Chromosome	10
Cytoband	q23.31
Chromosome location (bp)	88822132 - 88851818
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000152766 (version 83.38)
Entrez gene	118932
UniProt	Q5VYY1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q5VYY1
Antibodypedia	ANKRD22 antibodies

PROTEIN BROWSER

ANKRD22-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANKRD22-001 ENSP00000360998 ENST00000371930	Q5VYY1 [Direct mapping] Ankyrin repeat domain-containing protein 22 Show all	Phobius predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	191 aa 21.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.