Expression of SLC16A12 in cancer - Summary - The Human Protein Atlas

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SLC16A12

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	SLC16A12
Gene description	Solute carrier family 16, member 12
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (renal cancer)
HPA (cell line):	Cell line enriched (ASC TERT1)
HPA (normal tissue):	Tissue enhanced (epididymis, kidney)

Protein evidence

Evidence at transcript level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (renal cancer)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	SLC16A12 (HGNC Symbol)
Synonyms	MCT12
Description	Solute carrier family 16, member 12 (HGNC Symbol)
Entrez gene summary	This gene encodes a transmembrane transporter that likely plays a role in monocarboxylic acid transport. A mutation in this gene has been associated with juvenile cataracts with microcornea and renal glucosuria. [provided by RefSeq, Mar 2010]
Chromosome	10
Cytoband	q23.31
Chromosome location (bp)	89430299 - 89556641
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000152779 (version 83.38)
Entrez gene	387700
UniProt
neXtProt
Antibodypedia	SLC16A12 antibodies

PROTEIN BROWSER

SLC16A12-001	SLC16A12-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC16A12-001 ENSP00000360855 ENST00000371790	E9PSF9 [Direct mapping] Monocarboxylate transporter 12 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0015129 [lactate transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0035879 [plasma membrane lactate transport] GO:0055085 [transmembrane transport] Show all	516 aa 56.5 kDa	No	>9
SLC16A12-003 ENSP00000436965 ENST00000475682	E9PPP4 [Direct mapping] Monocarboxylate transporter 12 Show all	Predicted intracellular proteins Show all	GO:0015129 [lactate transmembrane transporter activity] GO:0035879 [plasma membrane lactate transport] Show all	25 aa 2.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.